Repository Community: null
http://hdl.handle.net/20.500.11750/1198
2024-03-29T05:56:00Z
2024-03-29T05:56:00Z
Feasibility Study on Magnetically Steerable Guidewire Device for Percutaneous Coronary Intervention
Jeong, Semi
Choi, Hyun Chul
Lee, Cheong
Ko, Seong Young
Park, Jong Oh
Park, Suk Ho
http://hdl.handle.net/20.500.11750/56371
2024-03-15T07:15:42Z
2017-01-31T15:00:00Z
Title: Feasibility Study on Magnetically Steerable Guidewire Device for Percutaneous Coronary Intervention
Author(s): Jeong, Semi; Choi, Hyun Chul; Lee, Cheong; Ko, Seong Young; Park, Jong Oh; Park, Suk Ho
Abstract: In this paper, we proposed a magnetically steerable guidewire device composed of two parts: steering part and feeding part. The steering part consists of a magnet attached to the end of a commercial guidewire and 2-pair Helmholtz coils, and the feeding part consists of a motorized stage and a device for holding the guidewire. In detail, the 2-pair Helmholtz coils generate a uniform magnetic field that can align the guidewire magnet in the region of interest (ROI) along a desired direction. In addition, the feeding part remotely controls guidewire insertion and the length of the flexible part of the guidewire extruded from a catheter. For accurate alignment at the end of the guidewire, we controlled the flexible length of the guidewire extruded from a catheter and the intensity and direction of the uniform magnetic field using the feed-forward method. In addition, to reduce alignment error due to unpredicted disturbances and friction effects between the test-bed and the guidewire, proportional-integralderivative control is introduced as a feedback control algorithm. Using the control algorithms, we demonstrated accurate actuation of the steerable guidewire device with a steering angle error of less than 0:5◦. We expect that the proposed steerable guidewire device can be applied to the development of a 3-D locomotive guidewire with position recognition for percutaneous coronary intervention (PCI). © 2016, Institute of Control, Robotics and Systems and The Korean Institute of Electrical Engineers and Springer-Verlag Berlin Heidelberg.
2017-01-31T15:00:00Z
위장관용 치료용 패치 및 이의 제조 방법
이지훈
방승민
박석호
http://hdl.handle.net/20.500.11750/48157
2024-03-07T13:40:13Z
Title: 위장관용 치료용 패치 및 이의 제조 방법
Author(s): 이지훈; 방승민; 박석호
Active Capsule System for Multiple Therapeutic Patch Delivery: Preclinical Evaluation
Lee, Jihun
Cuong, Hoang Manh
Kim, Jayoung
Choi, Eunho
Kee, Hyeonwoo
Yang, Seungun
Park, Jong-Oh
Park, Sukho
http://hdl.handle.net/20.500.11750/47935
2024-03-08T02:07:26Z
2023-10-01T15:00:00Z
Title: Active Capsule System for Multiple Therapeutic Patch Delivery: Preclinical Evaluation
Author(s): Lee, Jihun; Cuong, Hoang Manh; Kim, Jayoung; Choi, Eunho; Kee, Hyeonwoo; Yang, Seungun; Park, Jong-Oh; Park, Sukho
Abstract: Recently, active research has been conducted on the therapeutic functions of capsule endoscopes. Here, we propose an active capsule system that captures images of the interior of the gastrointestinal tract (GI) and actively delivers therapeutic patches. The active capsule system mainly comprises therapeutic patches, an active capsule equipped with a camera, and a robot-assisted magnetic actuator. The active capsule moves inside the GI tract via a magnetic actuator using a robot, captures pictures of the GI tract in actual time, and performs hemostatic treatment by delivering therapeutic patches to the target lesions. First, the fundamental performance of the active capsule system was verified via a hemostatic performance test of the therapeutic patch, patch contamination prevention test of the active capsule, and basic actuation test of the capsule. Second, multiple therapeutic patches were delivered to the gastric surface in an ex vivo test using an active capsule system. Finally, as a preclinical test, it was confirmed that the GI tract examination and the therapeutic patches delivery were possible using the active capsule system through an animal test using a porcine. Consequently, the proposed active capsule system represents a new paradigm for capsule endoscopy with multiple therapeutic patch delivery capabilities. © 2023 IEEE.
2023-10-01T15:00:00Z
A self-assembled three-dimensional hierarchical nanoflower: an efficient enzyme-mimetic material for cancer cell detection that improves ROS generation for therapy
Murugan, Chandran
Lee, Hyoryong
Park, Sukho
http://hdl.handle.net/20.500.11750/47645
2024-03-21T00:40:30Z
2023-12-31T15:00:00Z
Title: A self-assembled three-dimensional hierarchical nanoflower: an efficient enzyme-mimetic material for cancer cell detection that improves ROS generation for therapy
Author(s): Murugan, Chandran; Lee, Hyoryong; Park, Sukho
Abstract: Three-dimensional (3D) nanomaterials with high functional properties are emerging as the most promising artificial enzymes for overcoming the significant disadvantages of natural enzymes. Anticancer therapy using 3D-enzyme mimetic materials has emerged as an essential development for catalyzing cancer cell destruction. We report for the first time a novel 3D-based enzyme mimetic material, CaMoO4/MoS2/CuS nanoflower (CMC NF), that exhibits a large specific surface area, uniform flower-like structure, excellent biocompatibility, and high porosity, making it a suitable candidate for cancer detection and therapy. Additionally, CMC NFs were conjugated with folic acid (FA) to selectively target cancer cells, resulting in FA–CMC NFs explicitly binding to overexpressed folate receptor alpha (FRα) in MDA-MB-231 cells. Based on the peroxidase activity, the FA–CMC NFs are an effective nanoprobe for the selective detection of MDA-MB-231 cells over a wide detection range (50 to 5.5 × 104 cells per mL) with a low limit of detection (LOD) value of 10 cells per mL. In addition to their cancer detection capability, the FA–CMC NFs also effectively generated ˙OH radicals in a concentration-dependent manner to treat cancer cells. Under light conditions, the FA–CMC NFs with H2O2 solution showed efficient degradation of methylene blue (MB) dye, and the solution color appeared to fade within 15 min, indicating that they generated ˙OH radicals, which can efficiently kill cancer cells. Thus, the superior functionality of FA–CMC NFs offers cost-effective, facile, and reliable cancer cell detection, providing a new treatment option for cancer treatment and diagnosis. © The Royal Society of Chemistry 2024
2023-12-31T15:00:00Z