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The peripheral and central mechanisms underlying itch

Title
The peripheral and central mechanisms underlying itch
Authors
Lee, Jae SeungHan, Jasmin Sang HyunLee, Kyeong HoBang, Ju WonLee, Hyo Sang
Issue Date
2016-09
Type
Article
Keywords
BAM8-22ChloroquineCowhageDORSAL-HORN NEURONSEndothelinGASTRIN-RELEASING-PEPTIDEHistamineHISTAMINE-INDUCED ITCHHUMAN CEREBRAL-CORTEXItchMrgprA3MrgprC11NOXIOUS THERMAL STIMULIPOSITRON-EMISSION-TOMOGRAPHYPrimary afferentsPrimary sensory neuronsProtease-activated receptorPROTEASE-ACTIVATED RECEPTORSPruritogenPruritusSENSORY NEURONSSPINAL-CORDSPINOTHALAMIC TRACT NEURONS
ISSN
1976-6696
Abstract
Itch is one of the most distressing sensations that substantially impair quality of life. It is a cardinal symptom of many skin diseases and is also caused by a variety of systemic disorders. Unfortunately, currently available itch medications are ineffective in many chronic itch conditions, and they often cause undesirable side effects. To develop novel therapeutic strategies, it is essential to identify primary afferent neurons that selectively respond to itch mediators as well as the central nervous system components that process the sensation of itch and initiate behavioral responses. This review summarizes recent progress in the study of itch, focusing on itch-selective receptors, signaling molecules, neuronal pathways from the primary sensory neurons to the brain, and potential decoding mechanisms based on which itch is distinguished from pain.
URI
http://dx.doi.org/10.5483/BMBRep.2016.49.9.108
http://hdl.handle.net/20.500.11750/1021
Publisher
Bmb Reports
Files:
Collection:
Brain and Cognitive SciencesLaboratory of Affective Neuroscience1. Journal Articles


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