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Neuromodulation impact on nonlinear firing behavior of a reduced model motoneuron with the active dendrite

Title
Neuromodulation impact on nonlinear firing behavior of a reduced model motoneuron with the active dendrite
Authors
Kim, H[Kim, Hojeong]Heckman, CJ[Heckman, C. J.]
DGIST Authors
Kim, H[Kim, Hojeong]
Issue Date
2014-09-09
Citation
Frontiers in Computational Neuroscience, 8
Type
Article
Article Type
Article
Keywords
Cell FunctionComputer SimulationDendriteMathematical ModelMotoneuronsMotor Nerve ConductionNerve ConductionNervous System ParametersNeuromodulationNon-Linear FiringNon-Linear SystemPersistent Inward CurrentPersistent Inward CurrentsReduced ModelReduced Modeling
ISSN
1662-5188
Abstract
Neuromodulatory inputs from brainstem systems modulate the normal function of spinal motoneurons by altering the activation properties of persistent inward currents (PICs) in their dendrites. However, the effect of the PIC on firing outputs also depends on its location in the dendritic tree. To investigate the interaction between PIC neuromodulation and PIC location dependence, we used a two-compartment model that was biologically realistic in that it retains directional and frequency-dependent electrical coupling between the soma and the dendrites, as seen in multi-compartment models based on full anatomical reconstructions of motoneurons. Our two-compartment approach allowed us to systematically vary the coupling parameters between the soma and the dendrite to accurately reproduce the effect of location of the dendritic PIC on the generation of nonlinear (hysteretic) motoneuron firing patterns. Our results show that as a single parameter value for PIC activation was either increased or decreased by 20% from its default value, the solution space of the coupling parameter values for nonlinear firing outputs was drastically reduced by approximately 80%. As a result, the model tended to fire only in a linear mode at the majority of dendritic PIC sites. The same results were obtained when all parameters for the PIC activation simultaneously changed only by approximately ±10%. Our results suggest the democratization effect of neuromodulation: the neuromodulation by the brainstem systems may play a role in switching the motoneurons with PICs at different dendritic locations to a similar mode of firing by reducing the effect of the dendritic location of PICs on the firing behavior. © 2014 Kim and Heckman.
URI
http://hdl.handle.net/20.500.11750/1153
DOI
10.3389/fncom.2014.00110
Publisher
Frontiers Research Foundation
Related Researcher
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Collection:
ETCETC
Division of IoT∙Robotics Convergence Research1. Journal Articles


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