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Geometric effects of nano-hole arrays for label free bio-detection

Geometric effects of nano-hole arrays for label free bio-detection
Kim, S[Kim, Seunguk]Shin, JH[Shin, Jeong Hee]Kim, S[Kim, Samhwan]Yoo, SJ[Yoo, Seung-Jun]Jun, BO[Jun, Byoung Ok]Moon, C[Moon, Cheil]Jang, JE[Jang, Jae Eun]
DGIST Authors
Kim, S[Kim, Seunguk]; Shin, JH[Shin, Jeong Hee]; Kim, S[Kim, Samhwan]; Yoo, SJ[Yoo, Seung-Jun]; Jun, BO[Jun, Byoung Ok]; Moon, C[Moon, Cheil]; Jang, JE[Jang, Jae Eun]
Issue Date
RSC Advances, 6(11), 8935-8940
Article Type
BiomoleculesColorColor CoordinatesGeometric EffectsGeometryHigh ProbabilityNanohole ArraysPeak WavelengthReal-Time DetectionRefractive IndexSimple AnalysisVisible-Light Region
Geometric effects of nano-hole arrays were investigated for label free bio-detection. Because the nano-hole arrays were designed to present a filtered peak wavelength in the visible light region, filtered color changes caused by different biomolecules were easily observed with a microscope or even by the naked eye. Generally, many biomolecules are transparent or colorless in the visible range, so that it is hard to distinguish among them using visible observation. However, their molecular structure and composition induce some differences in the dielectric constant or refractive index causing a filtered color shift in the nano-hole array structure. Here, the contribution of geometric parameters such as the hole diameter and the spacing between nano-holes for bio-detection was evaluated to maximize the change in color among different biomolecules. A larger hole size and space between the holes enabled the biomolecules to be easily distinguished. Even if the change in color was not distinctive enough by eye in some cases, it was possible to distinguish the change by simple analysis of the 'Hue' values or by the 'Lab' color coordinates obtained from the photo images. Therefore, this technique can have high probability of realization for real-time detection of cells without the use of bio-markers. © The Royal Society of Chemistry 2016.
Royal Society of Chemistry
Related Researcher
  • Author Moon, Che Il Moon Lab
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
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Department of Brain and Cognitive SciencesMoon Lab1. Journal Articles

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