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Gene duplication of type-B ARR transcription factors systematically extends transcriptional regulatory structures in Arabidopsis
- Gene duplication of type-B ARR transcription factors systematically extends transcriptional regulatory structures in Arabidopsis
- Choi, SH[Choi, Seung Hee]; Hyeon, DY[Hyeon, Do Young]; Lee, IH[Lee, Il Hwan]; Park, SJ[Park, Su Jin]; Han, S[Han, Seungmin]; Lee, IC[Lee, In Chul]; Hwang, D[Hwang, Daehee]; Nam, HG[Nam, Hong Gil]
- DGIST Authors
- Hwang, D[Hwang, Daehee]; Nam, HG[Nam, Hong Gil]
- Issue Date
- Scientific Reports, 4
- Article Type
- Arabidopsis; Arabidopsis Protein; Arabidopsis Proteins; DNA-Binding Protein; DNA-Binding Proteins; Gene Duplication; Genetic Transcription; Genetics; Plant Root; Plant Roots; Signal Transduction; Transcription Factor; Transcription Factors; Transcription Initiation; Transcription, Genetic; Transcriptional Activation
- Many of duplicated genes are enriched in signaling pathways. Recently, gene duplication of kinases has been shown to provide genetic buffering and functional diversification in cellular signaling. Transcription factors (TFs) are also often duplicated. However, how duplication of TFs affects their regulatory structures and functions of target genes has not been explored at the systems level. Here, we examined regulatory and functional roles of duplication of three major ARR TFs (ARR1, 10, and 12) in Arabidopsis cytokinin signaling using wild-type and single, double, and triple deletion mutants of the TFs. Comparative analysis of gene expression profiles obtained from Arabidopsis roots in wild-type and these mutants showed that duplication of ARR TFs systematically extended their transcriptional regulatory structures, leading to enhanced robustness and diversification in functions of target genes, as well as in regulation of cellular networks of target genes. Therefore, our results suggest that duplication of TFs contributes to robustness and diversification in functions of target genes by extending transcriptional regulatory structures.
- Nature Publishing Group
- Related Researcher
Nam, Hong Gil
CBRG(Complex Biology Research Group)
Plant Senescence and Life History; Systems Biology; Complexbiology
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New BiologyCBRG(Complex Biology Research Group)1. Journal Articles
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