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Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation

Title
Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation
Authors
Kweon, HJ[Kweon, Hae-Jin]Suh, BC[Suh, Byung-Chang]
DGIST Authors
Kweon, HJ[Kweon, Hae-Jin]; Suh, BC[Suh, Byung-Chang]
Issue Date
2013-06-30
Citation
BMB Reports, 46(6), 295-304
Type
Article
Article Type
Review
Keywords
Acid-Sensing Ion ChannelAcid-Sensing Ion ChannelsAcid Sensing Ion Channel BlockersAcid Sensing Ion Channel Blocking AgentAcidosisChemistryG Protein-Coupled ReceptorG Protein-Coupled ReceptorsHumanHumansHydrogen-Ion ConcentrationIschemiaMetabolismModulationMultiple SclerosisNerve CellNeuronsPainPathologypHPhysiologyReceptors, G-Protein-CoupledSeizureSeizuresSignal Transduction
ISSN
1976-6696
Abstract
Extracellular acidification occurs not only in pathological conditions such as inflammation and brain ischemia, but also in normal physiological conditions such as synaptic transmission. Acid-sensing ion channels (ASICs) can detect a broad range of physiological pH changes during pathological and synaptic cellular activities. ASICs are voltage-independent, proton-gated cation channels widely expressed throughout the central and peripheral nervous system. Activation of ASICs is involved in pain perception, synaptic plasticity, learning and memory, fear, ischemic neuronal injury, seizure termination, neuronal degeneration, and mechanosensation. Therefore, ASICs emerge as potential therapeutic targets for manipulating pain and neurological diseases. The activity of these channels can be regulated by many factors such as lactate, Zn2+, and Phe-Met-Arg-Phe amide (FMRFamide)-like neuropeptides by interacting with the channel's large extracellular loop. ASICs are also modulated by G protein-coupled receptors such as CB1 cannabinoid receptors and 5-HT2. This review focuses on the physiological roles of ASICs and the molecular mechanisms by which these channels are regulated. © 2013 by the The Korean Society for Biochemistry and Molecular Biology.
URI
http://hdl.handle.net/20.500.11750/1605
DOI
10.5483/BMBRep.2013.46.6.121
Publisher
Korean Society for Molecular and Cellular Biology
Related Researcher
Files:
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Collection:
Brain and Cognitive SciencesETC1. Journal Articles


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