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Phosphoinositides regulate ion channels

Title
Phosphoinositides regulate ion channels
Authors
Hille, B[Hille, Bertil]Dickson, EJ[Dickson, Eamonn J.]Kruse, M[Kruse, Martin]Vivas, O[Vivas, Oscar]Suh, BC[Suh, Byung-Chang]
DGIST Authors
Suh, BC[Suh, Byung-Chang]
Issue Date
2015-06
Citation
Biochimica Et Biophysica Acta: Molecular and Cell Biology of Lipids, 1851(6), 844-856
Type
Article
Article Type
Review
Keywords
Calcium ChannelCalcium ChannelsCell MembraneChemistryChloride ChannelChloride ChannelsEpithelial Sodium ChannelEpithelial Sodium ChannelsG-Protein Coupled Receptor (GPCR)G Protein-Coupled ReceptorGene Expression RegulationGeneticsHumanHumansIon TransportMetabolismPhosphatidylinositol 4,5-BisphosphatePhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol 4,5 BisphosphatePhospholipase CPhospholipase C (PLC)Potassium ChannelPotassium ChannelsReceptors, G-Protein-CoupledSignal TransductionTransient Receptor Potential Channel (TRP Channel)Transient Receptor Potential ChannelsType C Phospholipases
ISSN
1388-1981
Abstract
Abstract Phosphoinositides serve as signature motifs for different cellular membranes and often are required for the function of membrane proteins. Here, we summarize clear evidence supporting the concept that many ion channels are regulated by membrane phosphoinositides. We describe tools used to test their dependence on phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate, and consider mechanisms and biological meanings of phosphoinositide regulation of ion channels. This lipid regulation can underlie changes of channel activity and electrical excitability in response to receptors. Since different intracellular membranes have different lipid compositions, the activity of ion channels still in transit towards their final destination membrane may be suppressed until they reach an optimal lipid environment. This article is part of a Special Issue entitled Phosphoinositides. © 2014 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/1662
DOI
10.1016/j.bbalip.2014.09.010
Publisher
Elsevier B.V.
Related Researcher
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesETC1. Journal Articles


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