Cited time in webofscience Cited time in scopus

Phosphoinositides regulate ion channels

Title
Phosphoinositides regulate ion channels
Author(s)
Hille, BertilDickson, Eamonn J.Kruse, MartinVivas, OscarSuh, Byung Chang
Issued Date
2015-06
Citation
Biochimica Et Biophysica Acta: Molecular and Cell Biology of Lipids, v.1851, no.6, pp.844 - 856
Type
Article
Author Keywords
Phosphatidylinositol 4,5-bisphosphatePhospholipase C (PLC)G-protein coupled receptor (GPCR)Potassium channelCalcium channelTransient receptor potential channel (TRP channel)
Keywords
ACTIVATED CA2+ CHANNELSCalcium ChannelCalcium ChannelsCell MembraneChemistryChloride ChannelChloride ChannelsEPITHELIAL NA+ CHANNELEpithelial Sodium ChannelEpithelial Sodium ChannelsG-BETA-GAMMAG-Protein Coupled Receptor (GPCR)G Protein Coupled ReceptorGene Expression RegulationGeneticsHumanHumansIon TransportLIVING CELLSMemBRANE PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATEMetabolismPHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATEPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol 4,5 BisphosphatePhospholipase CPhospholipase C (PLC)PLASMA-MemBRANEPotassium ChannelPotassium ChannelsPROTEIN-COUPLED RECEPTORSRAT SYMPATHETIC NEURONSReceptors, G-Protein-CoupledRECTIFYING K+ CHANNELSSignal TransductionTransient Receptor Potential ChannelTransient Receptor Potential Channel (Trp Channel)Transient Receptor Potential ChannelsType C Phospholipases
ISSN
1388-1981
Abstract
Abstract Phosphoinositides serve as signature motifs for different cellular membranes and often are required for the function of membrane proteins. Here, we summarize clear evidence supporting the concept that many ion channels are regulated by membrane phosphoinositides. We describe tools used to test their dependence on phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate, and consider mechanisms and biological meanings of phosphoinositide regulation of ion channels. This lipid regulation can underlie changes of channel activity and electrical excitability in response to receptors. Since different intracellular membranes have different lipid compositions, the activity of ion channels still in transit towards their final destination membrane may be suppressed until they reach an optimal lipid environment. This article is part of a Special Issue entitled Phosphoinositides. © 2014 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/1662
DOI
10.1016/j.bbalip.2014.09.010
Publisher
Elsevier B.V.
Related Researcher
  • 서병창 Suh, Byung-Chang
  • Research Interests Molecular mechanisms of epilepsy and sensory pain transmission; Signaling mechanism of ion channel regulation and membrane excitability; 분자전기생리; 간질 및 통증의 분자적 기전 연구
Files in This Item:

There are no files associated with this item.

Appears in Collections:
Department of Brain Sciences Laboratory of Brain Signal and Synapse Research 1. Journal Articles

qrcode

  • twitter
  • facebook
  • mendeley

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE