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Mechanosensitive channel stimulation system using low-intensity ultrasound by piezoelectric micromachined ultrasonic transducer array

Title
Mechanosensitive channel stimulation system using low-intensity ultrasound by piezoelectric micromachined ultrasonic transducer array
Authors
Lee, Won JunKim, Sam HwanJung, Joon TaekKang, Woo JinShin, Eun JungMoon, Che IlChoi, Hong Soo
DGIST Authors
Lee, Won Jun; Kim, Sam Hwan; Jung, Joon Taek; Kang, Woo Jin; Shin, Eun Jung; Moon, Che IlChoi, Hong Soo
Issue Date
2016
Citation
2016 IEEE International Ultrasonics Symposium, IUS 2016, 2016-November
Type
Conference
Article Type
Conference Paper
ISBN
9780000000000
ISSN
1948-5719
Abstract
In this research, piezoelectric micromachined ultrasonic transducer (pMUT) array was used for stimulation of mechanosensitive channel of HEK293T cells. The fabricated pMUT array was made by microelectromechanical system (MEMS) technology such as photo process, etching, sputtering, and sol-gel method. The resonance frequency and acoustic positive peak pressure were 2.07 MHz and 3.94 kPa, respectively. The proposed system can be used for ultrasonic stimulation and the result can be confirmed using fluorescence microscope by observing the cation changing in real-time. The cells were treated by fluorescence staining and transient receptor potential cation channel subfamily V member 1 (TRPV1) channel inserting. The Ca+ ion level of stimulated cell was changed by ultrasound. The result showed mechanosensitive channel was activated by ultrasound stimulation and observed influx of Ca+ ion in real-time. © 2016 IEEE.
URI
http://hdl.handle.net/20.500.11750/1725
DOI
10.1109/ULTSYM.2016.7728651
Publisher
IEEE Computer Society
Related Researcher
Files:
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Collection:
Brain and Cognitive SciencesMoon Lab2. Conference Papers
DGIST-ETH Microrobot Research Center2. Conference Papers


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