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Pharmacological intervention of early neuropathy in neurodegenerative diseases

Title
Pharmacological intervention of early neuropathy in neurodegenerative diseases
Authors
Kwon, M.J.[Kwon, Min Jee]Kim, J.-H.[Kim, Jeong Hoon]Kim, T.[Kim, Tae Soo]Lee, S.B.[Lee, Sung Bae]
DGIST Authors
Kwon, M.J.[Kwon, Min Jee]; Lee, S.B.[Lee, Sung Bae]
Issue Date
2017
Citation
Pharmacological Research, 119, 169-177
Type
Article
Article Type
Review
Keywords
Early NeuropathyEpigenetic ChangesNeurodegenerative DiseaseTranscriptional Dysregulation
ISSN
1043-6618
Abstract
Extensive studies have reported the significant roles of numerous cellular features and processes in properly maintaining neuronal morphology and function throughout the lifespan of an animal. Any alterations in their homeostasis appear to be strongly associated with neuronal aging and the pathogenesis of various neurodegenerative diseases, even before the occurrence of prominent neuronal death. However, until recently, the primary focus of studies regarding many neurodegenerative diseases has been on the massive cell death occurring at the late stages of disease progression. Thus, our understanding on early neuropathy in these diseases remains relatively limited. The complicated nature of various neuropathic features manifested early in neurodegenerative diseases suggests the involvement of a system-wide transcriptional regulation and epigenetic control. Epigenetic alterations and consequent changes in the neuronal transcriptome are now begun to be extensively studied in various neurodegenerative diseases. Upon the catastrophic incident of neuronal death in disease progression, it is utterly difficult to reverse the deleterious defects by pharmacological treatments, and therefore, therapeutics targeting the system-wide transcriptional dysregulation associated with specific early neuropathy is considered a better option. Here, we review our current understanding on the system-wide transcriptional dysregulation that is likely associated with early neuropathy shown in various neurodegenerative diseases and discuss the possible future developments of pharmaceutical therapeutics. © 2017 Elsevier Ltd
URI
http://hdl.handle.net/20.500.11750/2063
DOI
10.1016/j.phrs.2017.02.003
Publisher
Academic Press
Related Researcher
  • Author Lee, Sung Bae SB LAB(Lab of Neurodegenerative diseases and Aging)
  • Research Interests Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
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Collection:
Brain and Cognitive SciencesETC1. Journal Articles


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