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Decreased expression of 5-HT1A in the circumvallate taste cells in an animal model of depression

Title
Decreased expression of 5-HT1A in the circumvallate taste cells in an animal model of depression
Authors
Kim, D.[Kim, Doyun]Chung, S.[ Chung, Sena]Lee, S.H.[Lee, Sung Ho]Koo, J.H.[Koo, Jae Hyung]Lee, J.-H.[ Lee, Jong-Ho]Jahng, J.W.[ Jahng, Jeong Won]
DGIST Authors
Koo, J.H.[Koo, Jae Hyung]
Issue Date
2017
Citation
Archives of Oral Biology, 76, 42-47
Type
Article
Article Type
Article
Keywords
DepressionStressTaste Genes Expression
ISSN
0003-9969
Abstract
Objective It has been reported that stress can cause anhedonia, a core symptom of depression, and also affect taste responses of the stressed subjects. Anhedonia refers to a reduction of the ability to experience pleasure, which can be detected by decreased response to palatable food in rats. The present study was conducted to examine if stress-induced anhedonia is accompanied by changes in gene expression for taste. Design For anhedonia test, rats had free choices of cookies, a palatable food, and chow for 1 h following 1 h of daily restraint sessions. To examine the development of behavioral depression by restraint stress, ambulatory activity and forced swim tests were performed. Taste cells were harvested from the circumvallate papillae of rats on the 1st, 3rd and 7th day of stress exposure and subjected to the analysis of gene expression for taste. Results One hour of daily stress exposure did not affect chow intake during the entire experimental period. However, from day 2 cookie intake was suppressed, suggesting the development of anhedonia. Ambulatory activity was significantly decreased, and immobility during forced swim test was increased, after the 7th day of stress exposure, but not before. 5-HT1A mRNA expression, but not T1R2, T1R3, T2R6, ��-gustducin or PLC��2 mRNA expression, appeared to be decreased after the 3rd day of stress exposure. Conclusion Reduced expression of 5-HT1A in the taste cells, possibly leading to a reduced processing of taste information for palatable food, may additively contribute to the development of anhedonia as a pre-symptomatic feature of depression in stressed subjects. ? 2017 Elsevier Ltd
URI
http://hdl.handle.net/20.500.11750/2089
DOI
10.1016/j.archoralbio.2017.01.005
Publisher
Elsevier Ltd
Related Researcher
  • Author Koo, Jae Hyung The Koo Lab - ChemoReception Laboratory(CRLab)
  • Research Interests
Files:
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Collection:
New BiologyETC1. Journal Articles


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