Cross-protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTX(Vv)
- Title
- Cross-protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTX(Vv)
- Author(s)
- Lee, Tae Hee ; Cha, Sun-Shin ; Lee, Chang-Seop ; Rhee, Joon Haeng ; Woo, Hye Ryun ; Chung, Kyung Min
- Issued Date
- 2016-11
- Citation
- Microbiology and Immunology, v.60, no.11, pp.793 - 800
- Type
- Article
- Author Keywords
- cross-protection ; MARTX toxin ; monoclonal antibody ; Vibrio species
- Keywords
- ACCESSORY TOXINS ; AUTOPROCESSING RTX TOXIN ; B-SUBUNIT ; Cross-Protection ; CYSTEINE PROTEASE DOMAIN ; EL-TOR ; Martx Toxin ; Mice ; Monoclonal Antibody ; MOUSE MODEL ; PATHOGENESIS ; VACCINE ; Vibrio Species ; VIRULENCE
- ISSN
- 0385-5600
- Abstract
- Gram-negative Vibrio species secrete multifunctional autoprocessing repeats-in-toxin (MARTX) toxins associated with bacterial pathogenesis. Here, the cross-reactivity and cross-protectivity of mAbs against V. vulnificus RtxA1/MARTXVv was evaluated. Passive administration of any of these mAbs (21RA, 24RA, 46RA, 47RA and 50RA) provided strong protection against lethal V. cholerae infection. Interestingly, 24RA and 46RA, which map to the cysteine protease domain of V. cholerae MARTXVc, inhibited CPD autocleavage in vitro; this process is involved in V. cholerae pathogenesis. These results generate new insight into the development of broadly protective mAbs and/or vaccines against Vibrio species with MARTX toxins. © 2016 The Societies and John Wiley & Sons Australia, Ltd
- Publisher
- Wiley Blackwell
- Related Researcher
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Woo, Hye Ryun
- Research Interests Genome biology; Epigenomics; Plant senescence
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