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Cross-protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTX(Vv)

Title
Cross-protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTX(Vv)
Authors
Lee, TH[Lee, Tae Hee]Cha, SS[Cha, Sun-Shin]Lee, CS[Lee, Chang-Seop]Rhee, JH[Rhee, Joon Haeng]Woo, HR[Woo, Hye Ryun]Chung, KM[Chung, Kyung Min]
DGIST Authors
Woo, HR[Woo, Hye Ryun]
Issue Date
2016-11
Citation
Microbiology and Immunology, 60(11), 793-800
Type
Article
Article Type
Article
Keywords
Cross-ProtectionMartx ToxinMonoclonal AntibodyVibrio Species
ISSN
0385-5600
Abstract
Gram-negative Vibrio species secrete multifunctional autoprocessing repeats-in-toxin (MARTX) toxins associated with bacterial pathogenesis. Here, the cross-reactivity and cross-protectivity of mAbs against V. vulnificus RtxA1/MARTXVv was evaluated. Passive administration of any of these mAbs (21RA, 24RA, 46RA, 47RA and 50RA) provided strong protection against lethal V. cholerae infection. Interestingly, 24RA and 46RA, which map to the cysteine protease domain of V. cholerae MARTXVc, inhibited CPD autocleavage in vitro; this process is involved in V. cholerae pathogenesis. These results generate new insight into the development of broadly protective mAbs and/or vaccines against Vibrio species with MARTX toxins. © 2016 The Societies and John Wiley & Sons Australia, Ltd
URI
http://hdl.handle.net/20.500.11750/2163
DOI
10.1111/1348-0421.12449
Publisher
Wiley Blackwell
Related Researcher
Files:
There are no files associated with this item.
Collection:
New BiologyETC1. Journal Articles


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