Cited 1 time in webofscience Cited 2 time in scopus

The peripheral and central mechanisms underlying itch

Title
The peripheral and central mechanisms underlying itch
Authors
Lee, JS[Lee, Jae Seung]Han, JS[Han, Jasmin Sanghyun]Lee, K[Lee, Kyeongho]Bang, J[Bang, Juwon]Lee, H[Lee, Hyosang]
DGIST Authors
Lee, JS[Lee, Jae Seung]; Han, JS[Han, Jasmin Sanghyun]; Lee, K[Lee, Kyeongho]; Bang, J[Bang, Juwon]; Lee, H[Lee, Hyosang]
Issue Date
2016-09-30
Citation
BMB Reports, 49(9), 474-487
Type
Article
Article Type
Review
Keywords
BAM8-22ChloroquineCowhageEndothelinHistamineItchMrgprA3MrgprC11Primary AfferentsPrimary Sensory NeuronsProtease-Activated ReceptorPruritogenPruritus
ISSN
1976-6696
Abstract
Itch is one of the most distressing sensations that substantially impair quality of life. It is a cardinal symptom of many skin diseases and is also caused by a variety of systemic disorders. Unfortunately, currently available itch medications are ineffective in many chronic itch conditions, and they often cause undesirable side effects. To develop novel therapeutic strategies, it is essential to identify primary afferent neurons that selectively respond to itch mediators as well as the central nervous system components that process the sensation of itch and initiate behavioral responses. This review summarizes recent progress in the study of itch, focusing on itch-selective receptors, signaling molecules, neuronal pathways from the primary sensory neurons to the brain, and potential decoding mechanisms based on which itch is distinguished from pain. © 2016 by the The Korean Society for Biochemistry and Molecular Biology.
URI
http://hdl.handle.net/20.500.11750/2192
DOI
10.5483/BMBRep.2016.49.9.108
Publisher
Korean Society for Molecular and Cellular Biology
Related Researcher
  • Author Lee, Hyo Sang Laboratory of Affective Neuroscience
  • Research Interests Neuronal circuit mechanisms underlying emotional behaviors; 정서적 행동을 매개하는 신경회로 연구
Files:
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Collection:
Brain and Cognitive SciencesLaboratory of Affective Neuroscience1. Journal Articles


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