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dc.contributor.author Park, Yoo Jung ko
dc.contributor.author Lee, Sung Kyun ko
dc.contributor.author Jung, Young Su ko
dc.contributor.author Lee, Mingyu ko
dc.contributor.author Lee, Ha Young ko
dc.contributor.author Kim, Sang Doo ko
dc.contributor.author Park, Joon Seong ko
dc.contributor.author Koo, JaeHyung ko
dc.contributor.author Hwang, Jae Sam ko
dc.contributor.author Bae, Yoe-Sik ko
dc.date.available 2017-07-05T08:33:50Z -
dc.date.created 2017-04-10 -
dc.date.issued 2016-09 -
dc.identifier.citation BMB Reports, v.49, no.9, pp.520 - 525 -
dc.identifier.issn 1976-6696 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/2193 -
dc.description.abstract We investigated the effects of two antimicrobial peptides (AMPs) isolated from Scolopendra subspinipes mutilans on neutrophil activity. Stimulation of mouse neutrophils with the two AMPs elicited chemotactic migration of the cells in a pertussis toxin-sensitive manner. The two AMPs also stimulated activation of ERK and Akt, which contribute to chemotactic migration of neutrophils. We found that AMP-stimulated neutrophil chemotaxis was blocked by a formyl peptide receptor (FPR) 1 antagonist (cyclosporin H); moreover the two AMPs stimulated the chemotactic migration of FPR1-expressing RBL-2H3 cells but not of vector-expressing RBL- 2H3 cells. We also found that the two AMPs stimulate neutrophil migration in vivo, and that this effect is blocked in FPR1-deficient mice. Taken together, our results suggest that the two AMPs stimulate neutrophils, leading to chemotactic migration through FPR1, and the two AMPs will be useful for the study of FPR1 signaling and neutrophil activation. © 2016 by the The Korean Society for Biochemistry and Molecular Biology. -
dc.language English -
dc.publisher Korean Society for Molecular and Cellular Biology -
dc.title Promotion of formyl peptide receptor 1-mediated neutrophil chemotactic migration by antimicrobial peptides isolated from the centipede Scolopendra subspinipes mutilans -
dc.type Article -
dc.identifier.doi 10.5483/BMBRep.2016.49.9.098 -
dc.identifier.wosid 000384758800010 -
dc.identifier.scopusid 2-s2.0-84992317608 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.identifier.kciid ART002148538 -
dc.contributor.nonIdAuthor Park, Yoo Jung -
dc.contributor.nonIdAuthor Lee, Sung Kyun -
dc.contributor.nonIdAuthor Jung, Young Su -
dc.contributor.nonIdAuthor Lee, Mingyu -
dc.contributor.nonIdAuthor Lee, Ha Young -
dc.contributor.nonIdAuthor Kim, Sang Doo -
dc.contributor.nonIdAuthor Park, Joon Seong -
dc.contributor.nonIdAuthor Hwang, Jae Sam -
dc.contributor.nonIdAuthor Bae, Yoe-Sik -
dc.identifier.citationVolume 49 -
dc.identifier.citationNumber 9 -
dc.identifier.citationStartPage 520 -
dc.identifier.citationEndPage 525 -
dc.identifier.citationTitle BMB Reports -
dc.type.journalArticle Article -
dc.description.isOpenAccess Y -
dc.subject.keywordAuthor Antimicrobial peptide -
dc.subject.keywordAuthor Chemotaxis -
dc.subject.keywordAuthor Formyl peptide receptor 1 -
dc.subject.keywordAuthor Neutrophil -
dc.subject.keywordAuthor Scolopendra subspinipes mutilans -
dc.subject.keywordPlus SUPEROXIDE-PRODUCTION -
dc.subject.keywordPlus ESCHERICHIA-COLI -
dc.subject.keywordPlus PERTUSSIS-TOXIN -
dc.subject.keywordPlus CALCIUM INFLUX -
dc.subject.keywordPlus LIGAND -
dc.subject.keywordPlus IDENTIFICATION -
dc.subject.keywordPlus INFLAMMATION -
dc.subject.keywordPlus RECRUITMENT -
dc.subject.keywordPlus LYMPHOCYTE -
dc.subject.keywordPlus ACTIVATION -
dc.contributor.affiliatedAuthor Koo, JaeHyung -
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Department of New Biology Brain-Immune Axis Laboratory 1. Journal Articles

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