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Developmental programming modulates olfactory behavior in C. elegans via endogenous RNAi pathways

Title
Developmental programming modulates olfactory behavior in C. elegans via endogenous RNAi pathways
Authors
Sims, JR[Sims, Jennie R.]Ow, MC[Ow, Maria C.]Nishiguchi, MA[Nishiguchi, Mailyn A.]Kim, K[Kim, Kyuhyung]Sengupta, P[Sengupta, Piali]Hall, SE[Hall, Sarah E.]
DGIST Authors
Kim, K[Kim, Kyuhyung]
Issue Date
2016-06-28
Citation
eLife, 5
Type
Article
Article Type
Article
Keywords
Animal CellCaenorhabditis ElegansChromatin Assembly and DisassemblyControlled StudyDown-RegulationFluorescence in Situ HybridizationGene ExpressionImmunoprecipitationMutagenesisNon-HumanPolymerase Chain ReactionProtein ExpressionRNA InterferenceSmellingTransforming Growth Factor BetaZinc Finger Protein
ISSN
2050-084X
Abstract
Environmental stress during early development can impact adult phenotypes via programmed changes in gene expression. C. elegans larvae respond to environmental stress by entering the stress-resistant dauer diapause pathway and resume development once conditions improve (postdauers). Here we show that the osm-9 TRPV channel gene is a target of developmental programming and is down-regulated specifically in the ADL chemosensory neurons of postdauer adults, resulting in a corresponding altered olfactory behavior that is mediated by ADL in an OSM-9-dependent manner. We identify a cis-acting motif bound by the DAF-3 SMAD and ZFP-1 (AF10) proteins that is necessary for the differential regulation of osm-9, and demonstrate that both chromatin remodeling and endo-siRNA pathways are major contributors to the transcriptional silencing of the osm-9 locus. This work describes an elegant mechanism by which developmental experience influences adult phenotypes by establishing and maintaining transcriptional changes via RNAi and chromatin remodeling pathways.
URI
http://hdl.handle.net/20.500.11750/2257
DOI
10.7554/eLife.11642
Publisher
eLife Sciences Publications Ltd.
Related Researcher
  • Author Kim, Kyu Hyung The K. Kim Lab of Neurobehavior and Neural Circuits
  • Research Interests
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesETC1. Journal Articles


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