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Synchrotron Small-Angle X-ray Scattering Study of Cross-Linked Polymeric Micelles

Title
Synchrotron Small-Angle X-ray Scattering Study of Cross-Linked Polymeric Micelles
Author(s)
Kim, Hyun-ChulJin, Kyeong SikLee, Se GuenKim, EunjooLee, Seong JunJeong, Sang WonLee, Seung WooKim, Kwang-Woo
Issued Date
2016-06
Citation
Journal of Nanoscience and Nanotechnology, v.16, no.6, pp.6432 - 6439
Type
Article
Author Keywords
Polymeric MicellesCross-LinkingSynchrotron Small-Angle X-ray Scattering
Keywords
Amino ACIDsAQUEOUS-SOLUTIONBLOCK-COPOLYMER MICELLESCONTRAST-VARIATIONCORECross-Linked Polymeric MicellesCross-LinkingCross Linking AgentsCrosslinkingDestabilizing AgentsDRUG-DELIVERYDynamic Light ScatteringElectron MicroscopyEthyleneEthylene GlycolHigh Resolution Transmission Electron MicroscopyLight ScatteringLight TransmissionMicellesMotion Picture Experts Group StandardsNEUTRONPLA-PEG NANOPARTICLESPolymeric MicellePOLYMERIC MICELLESRing Opening PolymerizationSodium Dodecyl SulfateSodium SulfateSolutionsSTABILITYStructural ParameterSynchrotron Small-Angle X-Ray ScatteringSynchrotron Small Angle X-Ray ScatteringsSynchrotron X-Ray ScatteringTransmission Electron MicroscopyTransmission Electron Microscopy ImagesX Ray Scattering
ISSN
1533-4880
Abstract
Polymeric micelles of methoxypoly(ethylene glycol)-b-poly(lactide) containing lysine units (mPEG- PLA-Lys4) were cross-linked by reacting of lysine moieties with a bifunctional bis(N-hydroxysuccinimide ester). The micelles were characterized in aqueous solution using dynamic light scattering, transmission electron microscopy, and synchrotron small-angle X-ray scattering. The mPEG-PLA-Lys4 was synthesized through the ring-opening polymerization of N6-carbobenzyloxy- L-lysine N-carboxyanhydride with amine-terminated mPEG-PLA and subsequent deprotection. The polymeric micelles showed enhanced micelle stability after cross-linking, which was confirmed by adding sodium dodecyl sulfate as a destabilizing agent. The average diameters measured via dynamic light scattering were Delivered 19.1 nm by Ingenta and 29.2 nm for non-cross-linked polymeric micelles (NCPMs) and cross-linked polymeric micelles (CPMs), respectively. The transmission electron microscopy images showed that the size of the polymeric micelles increased slightly due to crosslinking, which was in good agreement with the DLS measurements. The overall structures and internal structural changes of NCPMs and CPMs in aqueous solution were studied in detail using synchrotron X-ray scattering method. According to the structural parameters of X-ray scattering analysis, CPMs with a more densely packed core structure were formed by reacting bifunctional cross-linking agents with lysine amino groups located in the innermost core of the polymeric micelles. Copyright © 2016 American Scientific Publishers All rights reserved.
URI
http://hdl.handle.net/20.500.11750/2268
DOI
10.1166/jnn.2016.12108
Publisher
American Scientific Publishers
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Appears in Collections:
Division of Biotechnology 1. Journal Articles
Division of Electronics & Information System 1. Journal Articles

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