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The level of autoantibodies targeting eukaryote translation elongation factor 1 Alpha1 and ubiquitin-conjugating enzyme 2L3 in nondiabetic young adults
- The level of autoantibodies targeting eukaryote translation elongation factor 1 Alpha1 and ubiquitin-conjugating enzyme 2L3 in nondiabetic young adults
- Kim, E.G.[Kim, Eun Hee G.]; Kwak, S.H.[Kwak, Soo Heon]; Hwang, D.[Hwang, Dae Hee]; Yi, E.C.[Yi, Eu Gene C.]; Park, K.S.[Park, Kyong Soo]; Koo, B.K.[Koo, Bo Kyung]; Kim, K.M.[Kim, Kristine M.]
- DGIST Authors
- Hwang, D.[Hwang, Dae Hee]
- Issue Date
- Diabetes and Metabolism Journal, 40(2), 154-160
- Article Type
- Adult; Age Distribution; Aged; Antibody Detection; Antigenic Variation; Autoantibodies; Autoantibody; Autoimmune Disease; Controlled Study; Diabetes Mellitus, Type 1; Enzyme Linked Immunosorbent Assay; Eukaryote Translation Elongation Factor 1 Alpha 1 Autoantibody; Female; Glutamate Decarboxylase Antibody; Glycosylated Hemoglobin; Human; Initiation Factor 1A; Initiation Factor 1A Autoantibody; Insulin Dependent Diabetes Mellitus; Major Clinical Study; Male; Onset Age; Prevalence; Protein Microarray; Ubiquitin-Conjugating Enzyme 2L3 Autoantibody; Ubiquitin Conjugating Enzyme; Ubiquitin Conjugating Enzyme 2L3; Ubiquitin Conjugating Enzyme 2L3 Autoantibody; Unclassified Drug; Young Adult
- Background: The prevalence of novel type 1 diabetes mellitus (T1DM) antibodies targeting eukaryote translation elongation factor 1 alpha 1 autoantibody (EEF1A1-AAb) and ubiquitin-conjugating enzyme 2L3 autoantibody (UBE2L3-AAb) has been shown to be negatively correlated with age in T1DM subjects. Therefore, we aimed to investigate whether age affects the levels of these two antibodies in nondiabetic subjects. Methods: EEF1A1-AAb and UBE2L3-AAb levels in nondiabetic control subjects (n=150) and T1DM subjects (n=101) in various ranges of age (18 to 69 years) were measured using an enzyme-linked immunosorbent assay. The cutoffpoint for the presence of each autoantibody was determined based on control subjects using the formula: [mean absorbance+3×standard deviation]. Results: In nondiabetic subjects, there were no significant correlations between age and EEF1A1-AAb and UBE2L3-AAb levels. However, there was wide variation in EEF1A1-AAb and UBE2L3-AAb levels among control subjects < 40 years old; the prevalence of both EEF1A1-AAb and UBE2L3-AAb in these subjects was 4.4%. When using cutoffpoints determined from the control subjects < 40 years old, the prevalence of both autoantibodies in T1DM subjects was decreased (EEFA1-AAb, 15.8% to 8.9%; UBE2L3-AAb, 10.9% to 7.9%) when compared to the prevalence using the cutoffderived from the totals for control subjects. Conclusion: There was no association between age and EEF1A1-AAb or UBE2L3-AAb levels in nondiabetic subjects. However, the wide variation in EEF1A1-AAb and UBE2L3-AAb levels apparent among the control subjects < 40 years old should be taken into consideration when determining the cutoffreference range for the diagnosis of T1DM. © 2016 Korean Diabetes Association.
- Korean Diabetes Association
- Related Researcher
Hwang, Dae Hee
Systems Biology and Medicine Lab
Multilayered spatiotemporal networks; Regulatory motifs or pathways; Metabolite-protein networks; Network stochasticity; Proteomics and informatics
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