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Valosin-containing protein (VCP): structure, functions, and implications in neurodegenerative diseases

Title
Valosin-containing protein (VCP): structure, functions, and implications in neurodegenerative diseases
Authors
Yeo, BK[Yeo, Bo Kyoung]Yu, SW[Yu, Seong-Woon]
DGIST Authors
Yeo, BK[Yeo, Bo Kyoung]; Yu, SW[Yu, Seong-Woon]
Issue Date
2016
Citation
Animal Cells and Systems, 20(6), 303-309
Type
Article
Article Type
Review
Keywords
ApoptosisAutophagyNeurodegenerative DiseaseUbiquitin-Proteasome SystemValosin-Containing Protein
ISSN
1976-8354
Abstract
Valosin-containing protein (VCP) is a hexameric protein belonging to the type II AAA+ (ATPases Associated with diverse cellular Activities) protein family. VCP governs multiple cellular processes and its diverse functions are determined by its interaction with a wide variety of partners and cofactors. Recently, mutations in VCP were suggested to cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia, amyotrophic lateral sclerosis, and Huntington’s disease. However, the pathogenic mechanisms of VCP mutations in these diseases are still largely unknown. In this review, we summarize the structure and cellular functions of VCP, especially focusing on apoptosis and two major cellular degradation pathways, the ubiquitin–proteasome system and autophagy. We also list the representative VCP mutations and discuss their potential association with neurodegenerative diseases. © 2016 Korean Society for Integrative Biology.
URI
http://hdl.handle.net/20.500.11750/2310
DOI
10.1080/19768354.2016.1259181
Publisher
Taylor and Francis Ltd.
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesLaboratory of Neuronal Cell Death1. Journal Articles


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