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Transcriptional regulatory network during development in the olfactory epithelium

Title
Transcriptional regulatory network during development in the olfactory epithelium
Authors
Im, S[Im, SeungYeong]Moon, C[Moon, Cheil]
DGIST Authors
Im, S[Im, SeungYeong]; Moon, C[Moon, Cheil]
Issue Date
2015-11
Citation
BMB Reports, 48(11), 599-608
Type
Article
Article Type
Article
ISSN
1976-6696
Abstract
Regeneration, a process of reconstitution of the entire tissue, occurs throughout life in the olfactory epithelium (OE). Regeneration of OE consists of several stages: proliferation of progenitors, cell fate determination between neuronal and non-neuronal lineages, their differentiation and maturation. How the differentiated cell types that comprise the OE are regenerated, is one of the central questions in olfactory developmental neurobiology. The past decade has witnessed considerable progress regarding the regulation of transcription factors (TFs) involved in the remarkable regenerative potential of OE. Here, we review current state of knowledge of the transcriptional regulatory networks that are powerful modulators of the acquisition and maintenance of developmental stages during regeneration in the OE. Advance in our understanding of regeneration will not only shed light on the basic principles of adult plasticity of cell identity, but may also lead to new approaches for using stem cells and reprogramming after injury or degenerative neurological diseases.
URI
http://hdl.handle.net/20.500.11750/2323
DOI
10.5483/BMBRep.2015.48.11.177
Publisher
Korean Society for Molecular and Cellular Biology
Related Researcher
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesETC1. Journal Articles


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