Cited 5 time in webofscience Cited 4 time in scopus

A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans

Title
A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans
Authors
Neal, SJ[Neal, Scott J.]Park, J[Park, JiSoo]DiTirro, D[DiTirro, Danielle]Yoon, J[Yoon, Jason]Shibuya, M[Shibuya, Mayumi]Choi, W[Choi, Woochan]Schroeder, FC[Schroeder, Frank C.]Butcher, RA[Butcher, Rebecca A.]Kim, K[Kim, Kyuhyung]Sengupta, P[Sengupta, Piali]
DGIST Authors
Park, J[Park, JiSoo]; Choi, W[Choi, Woochan]; Kim, K[Kim, Kyuhyung]
Issue Date
2016-05
Citation
G3: Genes, Genomes, Genetics, 6(5), 1475-1487
Type
Article
Article Type
Article
Keywords
C. ElegansCaenorhabditis ElegansCHE-12CHE-12 Ciliary GeneControlled StudyDauerGeneGene LocusGene MutationGenetic AnalysisGenetic ComplementationHormone DeterminationMACO-1Macoilin GeneNerve CellNociceptionNon-HumanPheromonePheromone Response Defective DauerPhosphotransferaseQUI-1Regulatory MechanismSignal TransductionTTBKTubulinUnclassified Drug
ISSN
2160-1836
Abstract
Animals must constantly assess their surroundings and integrate sensory cues to make appropriate behavioral and developmental decisions. Pheromones produced by conspecific individuals provide critical information regarding environmental conditions. Ascaroside pheromone concentration and composition are instructive in the decision of Caenorhabditis elegans to either develop into a reproductive adult or enter into the stress-resistant alternate dauer developmental stage. Pheromones are sensed by a small set of sensory neurons, and integrated with additional environmental cues, to regulate neuroendocrine signaling and dauer formation. To identify molecules required for pheromone-induced dauer formation, we performed an unbiased forward genetic screen and identified phd (pheromone response-defective dauer) mutants. Here, we describe new roles in dauer formation for previously identified neuronal molecules such as the WD40 domain protein QUI-1 and MACO-1 Macoilin, report new roles for nociceptive neurons in modulating pheromone-induced dauer formation, and identify tau tubulin kinases as new genes involved in dauer formation. Thus, phd mutants define loci required for the detection, transmission, or integration of pheromone signals in the regulation of dauer formation. © 2016 Neal et al.
URI
http://hdl.handle.net/20.500.11750/2542
DOI
10.1534/g3.115.026450
Publisher
Genetics Society of America
Related Researcher
  • Author Kim, Kyu Hyung The K. Kim Lab of Neurobehavior and Neural Circuits
  • Research Interests
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesETC1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE