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An Electrochemical Perspective Assay for Anticancer Activity of Calotropis Procera Against Glioblastoma Cell Line (LN-18) using Carbon Nanotubes-Graphene Nano-Conglomerate as a Podium

Title
An Electrochemical Perspective Assay for Anticancer Activity of Calotropis Procera Against Glioblastoma Cell Line (LN-18) using Carbon Nanotubes-Graphene Nano-Conglomerate as a Podium
Authors
Nalini, S.[Nalini, Seetharamaiah]Nandini, S.[Nandini, Seetharamaiah]Suresh, G.S.[Suresh, Gurukar Shivappa]Melo, J.S.[Melo, Jose Savio]Neelagund, S.E.[Neelagund, Shivayogeeswar E.]NaveenKumar, H.N.[NaveenKumar, Hunasepalya Nagaiah]Sanetuntikul, J.[Sanetuntikul, Jakkid]Shanmugam, S.[Shanmugam, Sangaraju]
DGIST Authors
Sanetuntikul, J.[Sanetuntikul, Jakkid]; Shanmugam, S.[Shanmugam, Sangaraju]
Issue Date
2016
Citation
Advanced Materials Letters, 7(12), 1003-1009
Type
Article
Article Type
Article
Keywords
Anti-Cancer AgentsBiological ActivityDNALN-18 CellsSoxhlet Assisted Extraction
ISSN
0976-3961
Abstract
In this article, we report the pre-screening of anti-cancer effect of Calotropis procera against glioblastoma cell lines (LN-18) by means of electrochemical methods. Soxhlet assisted extraction (SAE) has been employed to extract the polyphenol contents present in the leaf of Calotropis procera. The phytochemical analysis of the extract has been studied and the polyphenol contents were determined using Folin Ciocalteau method. To study the anticancer effects of the aqueous plant extract, a cytosensor (Gr/NT-G/LN-18) was fabricated and its possible mechanism for DNA binding was studied using graphite /poly(allylamine hydrochloride)/nanotube-graphene composite /polypyrrole /de-oxy ribonucleic acid (Gr/PAH/NT-G/PPy/DNA) modified electrode. The electrochemical characteristics of the proposed Gr/NT-G/LN-18 cytosensor towards the plant extract were evaluated using electrochemical techniques like cyclic voltammetry and differential pulse voltammetry. Scanning electron microscopy (SEM) and energy dispersive analysis of x-ray (EDAX) have been employed to study the physical characterization of the Gr/PAH/NT-G/PPy/DNA modified electrode. These results indicate that the plant extract has an ability to act as an antiglioblastoma against LN-18 cancer cells. Copyright © 2016 VBRI Press.
URI
http://hdl.handle.net/20.500.11750/2561
DOI
10.5185/amlett.2016.6395
Publisher
VBRI Press
Related Researcher
Files:
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Collection:
Energy Science and EngineeringAdvanced Energy Materials Laboratory1. Journal Articles


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