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dc.contributor.author Sims, Jessica D. -
dc.contributor.author Hwang, Jae Youn -
dc.contributor.author Wagner, Shawn -
dc.contributor.author Alonso-Valenteen, Felix -
dc.contributor.author Hanson, Chris -
dc.contributor.author Taguiam, Jan Michael -
dc.contributor.author Polo, Richard -
dc.contributor.author Harutyunyan, Ira -
dc.contributor.author Karapetyan, Gevorg -
dc.contributor.author Sorasaenee, Karn -
dc.contributor.author Ibrahim, Ahmed -
dc.contributor.author Marban, Eduardo -
dc.contributor.author Moats, Rex -
dc.contributor.author Gray, Harry B. -
dc.contributor.author Gross, Zeev -
dc.contributor.author Medina-Kauwe, Lali K. -
dc.date.available 2017-07-11T04:41:16Z -
dc.date.created 2017-04-10 -
dc.date.issued 2015-11-10 -
dc.identifier.issn 0168-3659 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/2580 -
dc.description.abstract Water-soluble corroles with inherent fluorescence can form stable self-assemblies with tumor-targeted cell penetration proteins, and have been explored as agents for optical imaging and photosensitization of tumors in pre-clinical studies. However, the limited tissue-depth of excitation wavelengths limits their clinical applicability. To examine their utility in more clinically-relevant imaging and therapeutic modalities, here we have explored the use of corroles as contrast enhancing agents for magnetic resonance imaging (MRI), and evaluated their potential for tumor-selective delivery when encapsulated by a tumor-targeted polypeptide. We have found that a manganese-metallated corrole exhibits significant T1 relaxation shortening and MRI contrast enhancement that is blocked by particle formation in solution but yields considerable MRI contrast after tissue uptake. Cell entry but not low pH enables this. Additionally, the corrole elicited tumor-toxicity through the loss of mitochondrial membrane potential and cytoskeletal breakdown when delivered by the targeted polypeptide. The protein-corrole particle (which we call HerMn) exhibited improved therapeutic efficacy compared to current targeted therapies used in the clinic. Taken together with its tumor-preferential biodistribution, our findings indicate that HerMn can facilitate tumor-targeted toxicity after systemic delivery and tumor-selective MR imaging activatable by internalization. © 2015 Elsevier B.V. All rights reserved. -
dc.publisher Elsevier B.V. -
dc.title A corrole nanobiologic elicits tissue-activated MRI contrast enhancement and tumor-targeted toxicity -
dc.type Article -
dc.identifier.doi 10.1016/j.jconrel.2015.08.046 -
dc.identifier.scopusid 2-s2.0-84940982858 -
dc.identifier.bibliographicCitation Journal of Controlled Release, v.217, pp.92 - 101 -
dc.subject.keywordAuthor Nanoparticle -
dc.subject.keywordAuthor Tumor-targeting -
dc.subject.keywordAuthor Corrole -
dc.subject.keywordAuthor Manganese -
dc.subject.keywordAuthor MRI -
dc.subject.keywordPlus AGENTS -
dc.subject.keywordPlus AMPHIPHILIC CORROLES -
dc.subject.keywordPlus Animal Cell -
dc.subject.keywordPlus Animal Experiment -
dc.subject.keywordPlus Animal Model -
dc.subject.keywordPlus Animal Tissue -
dc.subject.keywordPlus Article -
dc.subject.keywordPlus BREAST-CANCER -
dc.subject.keywordPlus Cell Membranes -
dc.subject.keywordPlus CELLS -
dc.subject.keywordPlus Contrast-Enhancing Agents -
dc.subject.keywordPlus Contrast Enhancement -
dc.subject.keywordPlus Contrast Medium -
dc.subject.keywordPlus Controlled Study -
dc.subject.keywordPlus Corrole -
dc.subject.keywordPlus Corroles -
dc.subject.keywordPlus DELIVERY -
dc.subject.keywordPlus Doxorubicin -
dc.subject.keywordPlus Drug Delivery System -
dc.subject.keywordPlus Excitation Wavelength -
dc.subject.keywordPlus Female -
dc.subject.keywordPlus Human -
dc.subject.keywordPlus Human Cell -
dc.subject.keywordPlus Magnetic Resonance Imaging -
dc.subject.keywordPlus Manganese -
dc.subject.keywordPlus METALLOCORROLES -
dc.subject.keywordPlus Mitochondria -
dc.subject.keywordPlus Mitochondrial Membrane Potential -
dc.subject.keywordPlus MODELS -
dc.subject.keywordPlus Mouse -
dc.subject.keywordPlus MRI -
dc.subject.keywordPlus Nanoparticle -
dc.subject.keywordPlus NANOPARTICLES -
dc.subject.keywordPlus Neoplasm -
dc.subject.keywordPlus Nonhuman -
dc.subject.keywordPlus Nuclear Magnetic Resonance Imaging -
dc.subject.keywordPlus Pertuzumab -
dc.subject.keywordPlus pH -
dc.subject.keywordPlus Polypeptide -
dc.subject.keywordPlus Polypyrroles -
dc.subject.keywordPlus Priority Journal -
dc.subject.keywordPlus Proteins -
dc.subject.keywordPlus RECEPTOR -
dc.subject.keywordPlus Systemic Deliveries -
dc.subject.keywordPlus Therapeutic Efficacy -
dc.subject.keywordPlus Therapeutic Modality -
dc.subject.keywordPlus Tissue -
dc.subject.keywordPlus Tissue Activated Magnetic Resonance Imaging Contrast Enhancement -
dc.subject.keywordPlus Toxicity -
dc.subject.keywordPlus TRAFFICKING -
dc.subject.keywordPlus Trastuzumab -
dc.subject.keywordPlus Tumor-Targeting -
dc.subject.keywordPlus Tumor Targeted Toxicity -
dc.subject.keywordPlus Tumor Targeting -
dc.subject.keywordPlus Tumors -
dc.subject.keywordPlus Unclassified Drug -
dc.citation.endPage 101 -
dc.citation.startPage 92 -
dc.citation.title Journal of Controlled Release -
dc.citation.volume 217 -
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Department of Electrical Engineering and Computer Science MBIS(Multimodal Biomedical Imaging and System) Laboratory 1. Journal Articles

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