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A Metabolomic Approach to Understanding the Metabolic Link between Obesity and Diabetes

Title
A Metabolomic Approach to Understanding the Metabolic Link between Obesity and Diabetes
Authors
Park, S[Park, Seokjae]Sadanala, KC[Sadanala, Krishna Chaitanya]Kim, EK[Kim, Eun-Kyoung]
DGIST Authors
Park, S[Park, Seokjae]; Sadanala, KC[Sadanala, Krishna Chaitanya]; Kim, EK[Kim, Eun-Kyoung]
Issue Date
2015-07
Citation
Molecules and Cells, 38(7), 587-596
Type
Article
Article Type
Review
Keywords
AcylcarnitineAmino AcidAmino Acid MetabolismBiological MarkerBiomarkersBranched Chain Amino AcidCarbohydrate MetabolismCardiovascular DiseaseDiabetesDiabetes MellitusDisease AssociationDyslipidemiaGlucoseHumanHypertensionInsulin ResistanceIsoleucineLeucineLipid MetabolismLysophosphatidylcholineMetabolic DisorderMetabolitesMetabolomicsNon-HumanNucleotideNucleotide MetabolismObesityReviewSphingomyelinValineXenobiotic Metabolism
ISSN
1016-8478
Abstract
Obesity and diabetes arise from an intricate interplay between both genetic and environmental factors. It is well recognized that obesity plays an important role in the development of insulin resistance and diabetes. Yet, the exact mechanism of the connection between obesity and diabetes is still not completely understood. Metabolomics is an analytical approach that aims to detect and quantify small metabolites. Recently, there has been an increased interest in the application of metabolomics to the identification of disease biomarkers, with a number of well-known biomarkers identified. Metabolomics is a potent approach to unravel the intricate relationships between metabolism, obesity and progression to diabetes and, at the same time, has potential as a clinical tool for risk evaluation and monitoring of disease. Moreover, metabolomics applications have revealed alterations in the levels of metabolites related to obesity-associated diabetes. This review focuses on the part that metabolomics has played in elucidating the roles of metabolites in the regulation of systemic metabolism relevant to obesity and diabetes. It also explains the possible metabolic relation and association between the two diseases. The metabolites with altered profiles in individual disorders and those that are specifically and similarly altered in both disorders are classified, categorized and summarized. © The Korean Society for Molecular and Cellular Biology.
URI
http://hdl.handle.net/20.500.11750/2595
DOI
10.14348/molcells.2015.0126
Publisher
Korean Society for Molecular and Cellular Biology
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesLab of Neuro-Metabolism & Neurometabolomic Research Center1. Journal Articles
ETC1. Journal Articles


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