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ADP-ribosylation Factor 6 (ARF6) Bidirectionally Regulates Dendritic Spine Formation Depending on Neuronal Maturation and Activity

Title
ADP-ribosylation Factor 6 (ARF6) Bidirectionally Regulates Dendritic Spine Formation Depending on Neuronal Maturation and Activity
Authors
Kim, Y[Kim, Yoonju]Lee, SE[Lee, Sang-Eun]Park, J[Park, Joohyun]Kim, M[Kim, Minhyung]Lee, B[Lee, Boyoon]Hwang, D[Hwang, Daehee]Chang, S[Chang, Sunghoe]
DGIST Authors
Hwang, D[Hwang, Daehee]
Issue Date
2015-03-20
Citation
Journal of Biological Chemistry, 290(12), 7323-7335
Type
Article
Article Type
Article
Keywords
4 Aminobutyric Acid A ReceptorActivation AnalysisActivity-DependentAdenosine Diphosphate Ribosylation FactorAdenosine Diphosphate Ribosylation Factor 6ADP-Ribosylation Factor 6ADP-Ribosylation FactorsAnimalAnimal CellAnimalsARF6 GeneBase SequenceCell ActivityCell CountCell CultureCell DensityCell MaturationCell StructureCell ViabilityCells, CulturedChemical ActivationControlled StudyCytologyDendritic SpineDendritic SpinesDown-RegulationDynamic ChangesEmbryologyFetusGene ExpressionGene Expression ProfilingGene Expression RegulationGeneticsHippocampusLong-Term PotentiationsLong Term PotentiationMicroarray AnalysisNerve CellNerve Cell DifferentiationNerve Cell PlasticityNeuronal ActivitiesNeuronal MorphologyNeuronsNon-HumanNucleotide SequenceP21 Activated Kinase 1Phosphatidic AcidPhosphatidylinositol 4 Phosphate KinasePhosphatidylinositol 4,5 BisphosphatePhospholipase DPhysiologyPicrotoxinPriority JournalProtein ExpressionProtein FunctionRac1 ProteinRatRatsRats, Sprague-DawleyRho Guanine Nucleotide Dissociation InhibitorRhoA Guanine Nucleotide Binding ProteinRNA, Small InterferingSignal TransductionSmall Interfering RnaSpine StructureSprague Dawley RatTetrodotoxinTranscription RegulationUpregulation
ISSN
0021-9258
Abstract
Recent studies have reported conflicting results regarding the role of ARF6 in dendritic spine development, but no clear answer for the controversy has been suggested. We found that ADP-ribosylation factor 6 (ARF6) either positively or negatively regulates dendritic spine formation depending on neuronal maturation and activity. ARF6 activation increased the spine formation in developing neurons, whereas it decreased spine density in mature neurons. Genome-wide microarray analysis revealed that ARF6 activation in each stage leads to opposite patterns of expression of a subset of genes that are involved in neuronal morphology. ARF6-mediated Rac1 activation via the phospholipase D pathway is the coincident factor in both stages, but the antagonistic RhoA pathway becomes involved in the mature stage. Furthermore, blocking neuronal activity in developing neurons using tetrodotoxin or enhancing the activity in mature neurons using picrotoxin or chemical long term potentiation reversed the effect of ARF6 on each stage. Thus, activity-dependent dynamic changes in ARF6-mediated spine structures may play a role in structural plasticity of mature neurons. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
URI
http://hdl.handle.net/20.500.11750/2606
DOI
10.1074/jbc.M114.634527
Publisher
American Society for Biochemistry and Molecular Biology Inc.
Related Researcher
  • Author Hwang, Dae Hee Systems Biology and Medicine Lab
  • Research Interests Multilayered spatiotemporal networks; Regulatory motifs or pathways; Metabolite-protein networks; Network stochasticity; Proteomics and informatics
Files:
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Collection:
New BiologyETC1. Journal Articles


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