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Bicuculline Ameliorated Chronic, but not Acute, Stress-Induced Feeding Suppression
- Bicuculline Ameliorated Chronic, but not Acute, Stress-Induced Feeding Suppression
- Lee, JY[Lee, Joo Young]; Kim, JY[Kim, Jin Young]; Ryu, V[Ryu, Vitaly]; Kim, BT[Kim, Bom-Taeck]; Koo, J[Koo, JaeHyung]; Lee, JH[Lee, Jong-Ho]; Jahng, JW[Jahng, Jeong Won]
- DGIST Authors
- Koo, J[Koo, JaeHyung]
- Issue Date
- International Journal of Pharmacology, 11(4), 335-342
- Article Type
- 4 Aminobutyric Acid; Animal Model; Animal Tissue; Arcuate Nucleus; Behavior Disorder; Bicuculline; Blood Analysis; Body Weight; Controlled Study; Corticosterone; Corticotropin Releasing Factor; Food Intake; Gamma-Amino Butyric Acid; Immobilization Stress; In Situ Hybridization; Male; mRNA Expression Assay; Neuropeptide Y; Neurotransmission; Non-Human; Protein Expression; Radioimmunoassay; Rat; Regulatory Mechanism; Stress; Stress Induced Feeding; Weight Gain; Weight Reduction
- This study was conducted to examine if γ-amino Butyric Acid (GABA)-ergic neurotransmission is implicated in the regulation of stress-induced feeding. Rats received GABAAreceptor antagonist bicuculline before each stress session during 10 days of daily restraint stress. The hypothalamic mRNA expressions of corticotropin-releasing hormone and neuropeptide Y were analyzed by in situ hybridization and the plasma corticosterone with radioimmunoassay. Bicuculline ameliorated the decrease in food intake by repeated restraints but not by a single restraint. Corticosterone increase responding to acute stress but not to repeated restraints was attenuated by bicuculline. Stress-induced expression of corticotropin-releasing hormone was blunted by bicuculline pre-treatm ent. Restraint stress did not affect neuropeptide Y expression, regardless of bicuculline pre-treatment. It is concluded that GABAAreceptors may mediate chronic but not acute, stress-induced suppression in food intake, possibly in relation with anorectic action of the hypothalamic corticotropin-releasing hormone and the hypothalamic neuropeptide Y may not be implicated in its regulatory mechanism. © Asian Network for Scientific Information.
- Asian Network for Scientific Information
- Related Researcher
Koo, Jae Hyung
The Koo Lab - ChemoReception Laboratory(CRLab)
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