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Bicuculline Ameliorated Chronic, but not Acute, Stress-Induced Feeding Suppression

Title
Bicuculline Ameliorated Chronic, but not Acute, Stress-Induced Feeding Suppression
Authors
Lee, JY[Lee, Joo Young]Kim, JY[Kim, Jin Young]Ryu, V[Ryu, Vitaly]Kim, BT[Kim, Bom-Taeck]Koo, J[Koo, JaeHyung]Lee, JH[Lee, Jong-Ho]Jahng, JW[Jahng, Jeong Won]
DGIST Authors
Koo, J[Koo, JaeHyung]
Issue Date
2015
Citation
International Journal of Pharmacology, 11(4), 335-342
Type
Article
Article Type
Article
Keywords
4 Aminobutyric AcidAnimal ModelAnimal TissueArcuate NucleusBehavior DisorderBicucullineBlood AnalysisBody WeightControlled StudyCorticosteroneCorticotropin Releasing FactorFood IntakeGamma-Amino Butyric AcidImmobilization StressIn Situ HybridizationMalemRNA Expression AssayNeuropeptide YNeurotransmissionNon-HumanProtein ExpressionRadioimmunoassayRatRegulatory MechanismStressStress Induced FeedingWeight GainWeight Reduction
ISSN
1811-7775
Abstract
This study was conducted to examine if γ-amino Butyric Acid (GABA)-ergic neurotransmission is implicated in the regulation of stress-induced feeding. Rats received GABAAreceptor antagonist bicuculline before each stress session during 10 days of daily restraint stress. The hypothalamic mRNA expressions of corticotropin-releasing hormone and neuropeptide Y were analyzed by in situ hybridization and the plasma corticosterone with radioimmunoassay. Bicuculline ameliorated the decrease in food intake by repeated restraints but not by a single restraint. Corticosterone increase responding to acute stress but not to repeated restraints was attenuated by bicuculline. Stress-induced expression of corticotropin-releasing hormone was blunted by bicuculline pre-treatm ent. Restraint stress did not affect neuropeptide Y expression, regardless of bicuculline pre-treatment. It is concluded that GABAAreceptors may mediate chronic but not acute, stress-induced suppression in food intake, possibly in relation with anorectic action of the hypothalamic corticotropin-releasing hormone and the hypothalamic neuropeptide Y may not be implicated in its regulatory mechanism. © Asian Network for Scientific Information.
URI
http://hdl.handle.net/20.500.11750/2620
DOI
10.3923/ijp.2015.335.342
Publisher
Asian Network for Scientific Information
Related Researcher
  • Author Koo, Jae Hyung The Koo Lab - ChemoReception Laboratory(CRLab)
  • Research Interests
Files:
There are no files associated with this item.
Collection:
New BiologyETC1. Journal Articles


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