Cited 4 time in webofscience Cited 5 time in scopus

Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides

Title
Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides
Authors
Artan, M[Artan, Murat]Jeong, DE[Jeong, Dae-Eun]Lee, D[Lee, Dongyeop]Kim, YI[Kim, Young-Il]Son, HG[Son, Heehwa G.]Husain, Z[Husain, Zahabiya]Kim, J[Kim, Jinmahn]Altintas, O[Altintas, Ozlem]Kim, K[Kim, Kyuhyung]Alcedo, J[Alcedo, Joy]Lee, SJV[Lee, Seung-Jae V.]
DGIST Authors
Kim, J[Kim, Jinmahn]
Issue Date
2016-05-01
Citation
Genes and Development, 30(9), 1047-1057
Type
Article
Article Type
Article
Keywords
AgingAssociationC. ElegansCaenorhabditis ElegansCaenorhabditis Elegans ProteinCaenorhabditis Elegans ProteinsCation ChannelCuesDAF-16 Protein, C. ElegansDAF-16/FOXODAF 28 ProteinEnvironmentFoodFood DeprivationForkhead Transcription FactorForkhead Transcription FactorsGene Expression RegulationGeneticsIns 6 ProteinInsulinInsulin-Like PeptideLifespanLongevityMetabolismNeuroendocrine Specific ProteinNon-HumanOptogeneticsPeptide HormonePeptide HormonesPhysiologyPriority JournalProtein ExpressionSensory Nerve CellSensory NeuronsSensory Receptor CellsSignal TransductionTax2 ProteinTax4 ProteinTranscription Factor Daf16Transcription Factor FOXOUnclassified Drug
ISSN
0890-9369
Abstract
Environmental fluctuations influence organismal aging by affecting various regulatory systems. One such system involves sensory neurons, which affect life span in many species. However, how sensory neurons coordinate organismal aging in response to changes in environmental signals remains elusive. Here, we found that a subset of sensory neurons shortens Caenorhabditis elegans’ life span by differentially regulating the expression of a specific insulin-like peptide (ILP), INS-6. Notably, treatment with food-derived cues or optogenetic activation of sensory neurons significantly increases ins-6 expression and decreases life span. INS-6 in turn relays the longevity signals to nonneuronal tissues by decreasing the activity of the transcription factor DAF-16/FOXO. Together, our study delineates a mechanism through which environmental sensory cues regulate aging rates by modulating the activities of specific sensory neurons and ILPs. © 2016 Artan et al.
URI
http://hdl.handle.net/20.500.11750/2688
DOI
10.1101/gad.279448.116
Publisher
Cold Spring Harbor Laboratory Press
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesThe K. Kim Lab of Neurobehavior and Neural Circuits1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE