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Mildly increased mechanical nociceptive sensitivity in REV-ERB Alpha knock-out mice

Title
Mildly increased mechanical nociceptive sensitivity in REV-ERB Alpha knock-out mice
Authors
Lee, J.[Lee, Jae Hyun]Ko, H.-G.[Ko, Hyoung Gon]Kim, K.[Kim, Kyung Jin]Kaang, B.-K.[Kaang, Bong Kiun]
DGIST Authors
Kim, K.[Kim, Kyung Jin]
Issue Date
2016
Citation
Experimental Neurobiology, 25(6), 342-346
Type
Article
Article Type
Article
Keywords
Circadian RhythmInflammatory PainNociceptionRev-Erb Alpha
ISSN
1226-2560
Abstract
Nociception is one of the most complex senses that is affected not only by external stimulation but also internal conditions. Previous studies have suggested that circadian rhythm is important in modulating nociception. REV-ERBα knock-out (KO) mice have disrupted circadian rhythm and altered mood-related phenotypes. In this study, we examined the role of REV-ERBα in inflammatory nociception. We found that the nociceptive sensitivity of KO mice was partially enhanced in mechanical nociception. However, this partial alteration was independent of the circadian rhythm. Taken together, deletion of REV-ERBα induced a mild change in mechanical nociceptive sensitivity but this alteration was not dependent on the circadian rhythm. © Experimental Neurobiology 2017.
URI
http://hdl.handle.net/20.500.11750/2762
DOI
10.5607/en.2016.25.6.342
Publisher
Korean Society for Neurodegenerative Disease
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesETC1. Journal Articles


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