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Micromagnet Conductors for High-Resolution Separation of Magnetically Driven Beads and Cells at Multiple Frequencies
- Micromagnet Conductors for High-Resolution Separation of Magnetically Driven Beads and Cells at Multiple Frequencies
- Hu, X[Hu, Xinghao]; Torati, SR[Torati, Sri Ramulu]; Shawl, AI[Shawl, Asif Iqbal]; Lim, B[Lim, Byeonghwa]; Kim, K[Kim, Kunwoo]; Kim, C[Kim, CheolGi]
- DGIST Authors
- Torati, SR[Torati, Sri Ramulu]; Shawl, AI[Shawl, Asif Iqbal]; Lim, B[Lim, Byeonghwa]; Kim, K[Kim, Kunwoo]; Kim, C[Kim, CheolGi]
- Issue Date
- IEEE Magnetics Letters, 7
- Article Type
- Biomagnetics; Cells; Critical Frequencies; Drag; High-Resolution Separations; In-Plane Rotating Field; Magnetic Susceptibility; Magnetism; Multi-Frequencies; Multi Frequency; Rotating Disks; Rotating Fields; Rotating Magnetic Fields; Selective Separation; Separation; Superparamagnetic Beads; Superparamagnetism
- We demonstrate a separation method for complex mixture of superparamagnetic beads using half-disk pathways, under an in-plane rotating magnetic field, which is highly sensitive to the bead size and magnetic susceptibility. The non-linear dynamics of the beads moving along the half-disk pathways at multiple frequencies can be divided into three regimes: a phase-locked regime at low driving frequencies, a phase-slipping regime above the first critical frequency fc1, and a phase-insulated regime above the second critical frequency fc2 in which the beads just hop at the gaps between two half-disks. Hence, based on the dynamical motions, the beads with varied sizes or heterogenic magnetic properties can be separated efficiently. Furthermore, a bio-selective separation of bead plus human monocytic leukemia (THP-1) cell complexes from bare beads has been achieved due to the increased drag force on the complexes, resulting in a decreased critical frequency. © 2010-2012 IEEE.
- Institute of Electrical and Electronics Engineers Inc.
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