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Jitter reduction technique for acoustic radiation force impulse microscopy via photoacoustic detection
- Jitter reduction technique for acoustic radiation force impulse microscopy via photoacoustic detection
- Kang, BJ[Kang, Bong Jin]; Yoon, C[Yoon, Changhan]; Park, JM[Park, Jin Man]; Hwang, JY[Hwang, Jae Youn]; Shung, KK[Shung, K. Kirk]
- DGIST Authors
- Park, JM[Park, Jin Man]; Hwang, JY[Hwang, Jae Youn]
- Issue Date
- Optics Express, 23(15), 19166-19175
- Article Type
- Acoustic Emissions; Acoustic Noise; Acoustic Radiation Force Impulse; Acoustic Radiators; Acoustic Wave Propagation; Acoustic Wave Transmission; Acoustic Waves; Breast Cancer Cells; Correlation Detectors; High Repetition Frequencies; Jitter; Photo-Acoustic Detection; Photo-Acoustic Effect; Photo-Acoustic Microscopy; Photo-Acoustic Signals; Quantitative Comparison; Reduction Techniques; Ultrasonic Applications; Ultrasonic Transducers; Ultrasound Transducers
- We demonstrate a jitter noise reduction technique for acoustic radiation force impulse microscopy via photoacoustic detection (PA-ARFI), which promises to be capable of measuring cell mechanics. To reduce the jitter noise induced by Q-switched pulsed laser operated at high repetition frequency, photoacoustic signals from the surface of an ultrasound transducer are aligned by cross-correlation and peak-to-peak detection, respectively. Each method is then employed to measure the displacements of a target sample in an agar phantom and a breast cancer cell due to ARFI application, followed by the quantitative comparison between their performances. The suggested methods for PA-ARFI significantly reduce jitter noises, thus allowing us to measure displacements of a target cell due to ARFI application by less than 3 μm. © 2015 Optical Society of America.
- OSA - The Optical Society
- Related Researcher
Hwang, Jae Youn
MBIS(Multimodal Biomedical Imaging and System) Laboratory
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