Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, So Yeun | - |
dc.contributor.author | Yoo, Seung-Jun | - |
dc.contributor.author | Ronnett, Gabriele V. | - |
dc.contributor.author | Kim, Eun-Kyoung | - |
dc.contributor.author | Moon, Cheil | - |
dc.date.available | 2017-07-11T05:57:43Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/2894 | - |
dc.description.abstract | Olfactory stimulation activates multiple signaling cascades in order to mediate activity-driven changes in gene expression that promote neuronal survival. To date, the mechanisms involved in activity-dependent olfactory neuronal survival have yet to be fully elucidated. In the current study, we observed that olfactory sensory stimulation, which caused neuronal activation, promoted activation of the phosphatidylinositol 3’-kinase (PI3K)/Akt pathway and the expression of Bcl-2, which were responsible for olfactory receptor neuron (ORN) survival. We demonstrated that Bcl-2 expression increased after odorant stimulation both in vivo and in vitro. We also showed that odorant stimulation activated Akt, and that Akt activation was completely blocked by incubation with both a PI3K inhibitor (LY294002) and Akt1 small interfering RNA. Moreover, blocking the PI3K/Akt pathway diminished the odorantinduced Bcl-2 expression, as well as the effects on odorant-induced ORN survival. A temporal difference was noted between the activation of Akt1 and the expression of Bcl-2 following odorant stimulation. Blocking the PI3K/Akt pathway did not affect ORN survival in the time range prior to the increase in Bcl-2 expression, implying that these two events, activation of the PI3K pathway and Bcl-2 induction, were tightly connected to promote post-translational ORN survival. Collectively, our results indicated that olfactory activity activated PI3K/Akt, induced Bcl-2, and promoted long term ORN survival as a result. © The Korean Society for Molecular and Cellular Biology. All rights reserved. | - |
dc.language | English | - |
dc.publisher | Korean Society for Molecular and Cellular Biology | - |
dc.title | Odorant Stimulation Promotes Survival of Rodent Olfactory Receptor Neurons via PI3K/Akt Activation and Bcl-2 Expression | - |
dc.type | Article | - |
dc.identifier.doi | 10.14348/molcells.2015.0038 | - |
dc.identifier.scopusid | 2-s2.0-84944069433 | - |
dc.identifier.bibliographicCitation | Molecules and Cells, v.38, no.6, pp.535 - 539 | - |
dc.identifier.kciid | ART001997896 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordAuthor | Bcl-2 | - |
dc.subject.keywordAuthor | odorant | - |
dc.subject.keywordAuthor | olfactory receptor neuron | - |
dc.subject.keywordAuthor | PI3K/Akt | - |
dc.subject.keywordAuthor | survival | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | PROTEIN FAMILY | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | TARGET | - |
dc.citation.endPage | 539 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 535 | - |
dc.citation.title | Molecules and Cells | - |
dc.citation.volume | 38 | - |
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