Cited 3 time in
Cited 7 time in
High-frequency dual mode pulsed wave Doppler imaging for monitoring the functional regeneration of adult zebrafish hearts
- High-frequency dual mode pulsed wave Doppler imaging for monitoring the functional regeneration of adult zebrafish hearts
- Kang, BJ[Kang, Bong Jin]; Park, J[Park, Jinhyoung]; Kim, J[Kim, Jieun]; Kim, HH[Kim, Hyung Ham]; Lee, C[Lee, Changyang]; Hwang, JY[Hwang, Jae Youn]; Lien, CL[Lien, Ching-Ling]; Shung, KK[Shung, K. Kirk]
- DGIST Authors
- Hwang, JY[Hwang, Jae Youn]
- Issue Date
- Journal of the Royal Society Interface, 12(103)
- Article Type
- Amputation; Animal Experiment; Animal Model; Animalia; Artificial Limbs; B Scan; Coronary Artery Blood Flow; Danio Rerio; Diastolic Dysfunction; Doppler; Doppler Echo; Doppler Echocardiography; Doppler Echography; Doppler Flow; Doppler Flowmetry; Dual Mode Pulsed Wave Doppler Imaging; Echocardiography; Flow Rate; Flow Velocity; Functional Regeneration; Heart; Heart Cycle; Heart Movement; Heart Regeneration; Heart Valve Motion; In Vivo Study; Longitudinal Study; Non-Human; Phantom; Post-Operative Period; Quantitative Analysis; Tissue; Tissue Doppler; Tissue Doppler Imaging; Tissue Regeneration; Ultrasonic Imaging; Ultrasound Imaging Systems; Ultrasound Transducer; Zebrafish; Zebrafish Heart Regenerations
- Adult zebrafish is a well-known small animal model for studying heart regeneration. Although the regeneration of scars made by resecting the ventricular apex has been visualized with histological methods, there is no adequate imaging tool for tracking the functional recovery of the damaged heart. For this reason, high-frequency Doppler echocardiography using dual mode pulsed wave Doppler, which provides both tissue Doppler (TD) and Doppler flow in a same cardiac cycle, is developed with a 30 MHz high-frequency array ultrasound imaging system. Phantom studies show that the Doppler flow mode of the dual mode is capable of measuring the flow velocity from 0.1 to 15 cm s(-1) with high accuracy (p-value = 0.974 > 0.05). In the in vivo study of zebrafish, both TD and Doppler flow signals were simultaneously obtained from the zebrafish heart for the first time, and the synchronized valve motions with the blood flow signals were identified. In the longitudinal study on the zebrafish heart regeneration, the parameters for diagnosing the diastolic dysfunction, for example, E/Em < 10, E/A < 0.14 for wild-type zebrafish, were measured, and the type of diastolic dysfunction caused by the amputation was found to be similar to the restrictive filling. The diastolic function was fully recovered within four weeks post-amputation. © 2014 The Author(s) Published by the Royal Society. All rights reserved.
- Royal Society of Chemistry
- Related Researcher
Hwang, Jae Youn
MBIS(Multimodal Biomedical Imaging and System) Laboratory
There are no files associated with this item.
- Information and Communication EngineeringETC1. Journal Articles
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.