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dc.contributor.author Choi, Daeseok -
dc.contributor.author Choi, Jaemyung -
dc.contributor.author Kang, Byeongsoo -
dc.contributor.author Lee, Seungchul -
dc.contributor.author Cho, Young-hyun -
dc.contributor.author Hwang, Ildoo -
dc.contributor.author Hwang, Daehee -
dc.date.available 2017-07-11T06:21:39Z -
dc.date.created 2017-04-10 -
dc.date.issued 2014-05 -
dc.identifier.issn 1674-2052 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/3092 -
dc.description.abstract Integration of internal and external cues into developmental programs is indispensable for growth and development of plants, which involve complex interplays among signaling pathways activated by the internal and external factors (IEFs). However, decoding these complex interplays is still challenging. Here, we present a web-based platform that identifies key regulators and Network models delineating Interplays among Developmental signaling (iNID) in Arabidopsis. iNID provides a comprehensive resource of (1) transcriptomes previously collected under the conditions treated with a broad spectrum of IEFs and (2) protein and genetic interactome data in Arabidopsis. In addition, iNID provides an array of tools for identifying key regulators and network models related to interplays among IEFs using transcriptome and interactome data. To demonstrate the utility of iNID, we investigated the interplays of (1) phytohormones and light and (2) phytohormones and biotic stresses. The results revealed 34 potential regulators of the interplays, some of which have not been reported in association with the interplays, and also network models that delineate the involvement of the 34 regulators in the interplays, providing novel insights into the interplays collectively defined by phytohormones, light, and biotic stresses. We then experimentally verified that BME3 and TEM1, among the selected regulators, are involved in the auxin-brassinosteroid (BR)-blue light interplay. Therefore, iNID serves as a useful tool to provide a basis for understanding interplays among IEFs. © The Author 2013. -
dc.publisher Cell Press -
dc.title iNID: An Analytical Framework for Identifying Network Models for Interplays among Developmental Signaling in Arabidopsis -
dc.type Article -
dc.identifier.doi 10.1093/mp/sst173 -
dc.identifier.scopusid 2-s2.0-84900520191 -
dc.identifier.bibliographicCitation Molecular Plant, v.7, no.5, pp.792 - 813 -
dc.subject.keywordAuthor transcriptome analysis -
dc.subject.keywordAuthor network analysis -
dc.subject.keywordAuthor signal interplays -
dc.subject.keywordAuthor development -
dc.subject.keywordAuthor Arabidopsis -
dc.subject.keywordPlus DATA INTEGRATION METHODOLOGY -
dc.subject.keywordPlus PROTEIN-INTERACTION NETWORK -
dc.subject.keywordPlus SYSTEMS-BIOLOGY -
dc.subject.keywordPlus TRANSCRIPTION FACTOR -
dc.subject.keywordPlus GENE-EXPRESSION -
dc.subject.keywordPlus PLANT-GROWTH -
dc.subject.keywordPlus NECROTROPHIC PATHOGENS -
dc.subject.keywordPlus STRESS RESPONSES -
dc.subject.keywordPlus HYPOCOTYL GROWTH -
dc.subject.keywordPlus SEED-GERMINATION -
dc.citation.endPage 813 -
dc.citation.number 5 -
dc.citation.startPage 792 -
dc.citation.title Molecular Plant -
dc.citation.volume 7 -
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Department of New Biology Systems Biology and Medicine Lab 1. Journal Articles

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