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Protective effects of inducible HO-1 on oxygen toxicity in rat brain endothelial microvessel cells

Title
Protective effects of inducible HO-1 on oxygen toxicity in rat brain endothelial microvessel cells
Authors
Yoo, S.-J.[Yoo, Seung Jun]Nakra, N.K.[Nakra, Neal K.]Ronnett, G.V.[Ronnett, Gabriele V.]Moon, C.[Moon, Che Il]
DGIST Authors
Yoo, S.-J.[Yoo, Seung Jun]; Ronnett, G.V.[Ronnett, Gabriele V.]; Moon, C.[Moon, Che Il]
Issue Date
2014
Citation
Endocrinology and Metabolism, 29(3), 356-362
Type
Article
Article Type
Article
Keywords
BilirubinCarbon MonoxideHemeIronOxygenases
ISSN
2093-596X
Abstract
Background: Reperfusion in ischemia is believed to generate cytotoxic oxidative stress, which mediates reperfusion injury. These stress conditions can initiate lipid peroxidation and damage to proteins, as well as promote DNA strand breaks. As biliverdin and bilirubin produced by heme oxygenase isoform 1 (HO-1) have antioxidant properties, the production of both antioxidants by HO-1 may help increase the resistance of the ischemic brain to oxidative stress. In the present study, the survival effect of HO-1 was confirmed using hemin. Methods: To confirm the roles of HO-1, carbon monoxide, and cyclic guanosine monophosphate further in the antioxidant effect of HO-1 and bilirubin, cells were treated with cycloheximide, desferoxamine, and zinc deuteroporphyrin IX 2,4 bis glycol, respectively. Results: HO-1 itself acted as an antioxidant. Furthermore, iron, rather than carbon monoxide, was involved in the HO-1-mediated survival effect. HO-1 activity was also important in providing bilirubin as an antioxidant. Conclusion: Our results suggested that HO-1 helped to increase the resistance of the ischemic brain to oxidative stress. © 2014 Korean Endocrine Society.
URI
http://hdl.handle.net/20.500.11750/3135
DOI
10.3803/EnM.2014.29.3.356
Publisher
Korean Endocrine Society
Related Researcher
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesETC1. Journal Articles
Brain and Cognitive SciencesETC1. Journal Articles


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