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Application of elastin-mimetic recombinant proteins in chemotherapeutics delivery, cellular engineering, and regenerative medicine

Title
Application of elastin-mimetic recombinant proteins in chemotherapeutics delivery, cellular engineering, and regenerative medicine
Authors
Jeon, WB[Jeon, Won Bae]
DGIST Authors
Jeon, WB[Jeon, Won Bae]
Issue Date
2013-11
Citation
Bioengineered, 4(6), 368-373
Type
Article
Article Type
Article; Note
Keywords
AnimalAnimalsBio-Compatible MaterialsBiomaterialBiomimeticsBiopolymerBiopolymersCell EngineeringChemistryDrug and Gene DeliveryDrug Delivery SystemDrug Delivery SystemsElastinElastin-Like ProteinsExtracellular MatrixGene TransferGene Transfer TechniquesGenetic EngineeringHumanHumansHydrogelHydrogelsMethodologyRecombinant ProteinRecombinant ProteinsRegenerative MedicineSurface-Coatings
ISSN
2165-5979
Abstract
With the remarkable increase in the fields of biomedical engineering and regenerative medicine, biomate-rial design has become an indispensable approach for developing the biocompat-ible carriers for drug or gene cargo and extracellular matrix (ECM) for cell survival, proliferation and differentiation. Native ECM materials derived from animal tissues were believed to be the best choices for tissue engineering. However, possible pathogen contamination by cellular remnants from foreign animal tissues is an unavoidable issue that has limited the use of native ECM for human benefit. Some synthetic polymers have been used as alternative materials for manufacturing native ECM because of the biodegradability and ease of large-scale production of the polymers. However, the inherent polydispersity of the polymers causes batch-to-batch variation in polymer composition and possible cytotoxic interactions between chemical matrices and neighboring cells or tissues have not yet been fully resolved. Elastin-like proteins (ELPs) are genetically engineered biopolymers modeled after the naturally occurring tropoelastin and have emerged as promising materials for biomedical applications because they are biocompatible, non-immunogenic and biodegradable, and their composition, mechanical stiffness and even fate within the cell can be controlled at the gene level. This commentary highlights the recent progresses in the development of the ELP-based recombinant proteins that are being increasingly used for the delivery of chemotherapeutics and to provide a cell-friendly ECM environment. © 2013 Landes Bioscience.
URI
http://hdl.handle.net/20.500.11750/3184
DOI
10.4161/bioe.24158
Publisher
LANDES BIOSCIENCE
Related Researcher
Files:
There are no files associated with this item.
Collection:
Companion Diagnostics and Medical Technology Research Group1. Journal Articles


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