Department of Energy Science and Engineering
Electrochemistry Laboratory for Sustainable Energy(ELSE)
1. Journal Articles
Non-Cross-Bridged Tetraazamacrocyclic Chelator for Stable Cu-64-Based Radiopharmaceuticals
- Title
- Non-Cross-Bridged Tetraazamacrocyclic Chelator for Stable Cu-64-Based Radiopharmaceuticals
- Author(s)
- Dale, Ajit V. ; Pandya, Darpan N. ; Kim, Jung Young ; Lee, Hochun ; Ha, Yeong Su ; Bhatt, Nikunj ; Kim, Jonghee ; Seo, Jeong Ju ; Lee, Woonghee ; Kim, Sung Hong ; Yoon, Young-Ran ; An, Gwang Il ; Yoo, Jeongsoo
- Issued Date
- 2013-10
- Citation
- ACS Medicinal Chemistry Letters, v.4, no.10, pp.927 - 931
- Type
- Article
- Author Keywords
- Bifunctional chelator ; copper complex ; imaging agent ; radiopharmaceutical
- Keywords
- IN-VIVO STABILITY ; COMPLEXES ; COPPER(II) ; COPPER-64 ; CYCLAM ; BIODISTRIBUTION ; MACROCYCLES ; DERIVATIVES ; CHEMISTRY ; BEHAVIOR
- ISSN
- 1948-5875
- Abstract
- N-mono/dimethylated TE2A tetraazamacrocycles (MM-TE2A and DM-TE2A) were synthesized in high yields. Both Cu-MM/DM-TE2A complexes showed increased kinetic stability compared to that of Cu-TE2A, whereas Cu-DM-TE2A showed even higher in vitro stability than that of Cu-ECB-TE2A. MM-TE2A and DM-TE2A were quantitatively radiolabeled with 64Cu ions and showed rapid clearance from the body to emerge as a potential efficient bifunctional chelator. © 2013 American Chemical Society.
- Publisher
- American Chemical Society
- Related Researcher
-
-
Lee, Hochun
- Research Interests Lithium-ion batteries; Novel Materials for rechargeable batteries; Novel energy conversion;storage systems; Electrochemistry; 리튬이차전지; 이차전지용 신규 전극 및 전해액; 신규 에너지변환 및 저장 시스템; 전기화학
-
- Files in This Item:
-
There are no files associated with this item.
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.