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Non-Cross-Bridged Tetraazamacrocyclic Chelator for Stable Cu-64-Based Radiopharmaceuticals

Title
Non-Cross-Bridged Tetraazamacrocyclic Chelator for Stable Cu-64-Based Radiopharmaceuticals
Authors
Dale, AV[Dale, Ajit V.]Pandya, DN[Pandya, Darpan N.]Kim, JY[Kim, Jung Young]Lee, H[Lee, Hochun]Ha, YS[Ha, Yeong Su]Bhatt, N[Bhatt, Nikunj]Kim, J[Kim, Jonghee]Seo, JJ[Seo, Jeong Ju]Lee, W[Lee, Woonghee]Kim, SH[Kim, Sung Hong]Yoon, YR[Yoon, Young-Ran]An, GI[An, Gwang Il]Yoo, J[Yoo, Jeongsoo]
DGIST Authors
Lee, H[Lee, Hochun]
Issue Date
2013-10
Citation
ACS Medicinal Chemistry Letters, 4(10), 927-931
Type
Article
Article Type
Article
Keywords
Bi-Functional ChelatorCopper 64Copper ComplexImaging AgentIsotope LabelingMacrocyclic CompoundPriority JournalRadiopharmaceutical
ISSN
1948-5875
Abstract
N-mono/dimethylated TE2A tetraazamacrocycles (MM-TE2A and DM-TE2A) were synthesized in high yields. Both Cu-MM/DM-TE2A complexes showed increased kinetic stability compared to that of Cu-TE2A, whereas Cu-DM-TE2A showed even higher in vitro stability than that of Cu-ECB-TE2A. MM-TE2A and DM-TE2A were quantitatively radiolabeled with 64Cu ions and showed rapid clearance from the body to emerge as a potential efficient bifunctional chelator. © 2013 American Chemical Society.
URI
http://hdl.handle.net/20.500.11750/3198
DOI
10.1021/ml400142s
Publisher
American Chemical Society
Related Researcher
  • Author Lee, Ho Chun Electrochemistry Laboratory for Sustainable Energy(ELSE)
  • Research Interests Lithium-ion batteries; Novel Materials for rechargeable batteries; Novel energy conversion;storage systems; Electrochemistry; 리튬이차전지; 이차전지용 신규 전극 및 전해액; 신규 에너지변환 및 저장 시스템; 전기화학
Files:
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Collection:
Energy Science and EngineeringElectrochemistry Laboratory for Sustainable Energy(ELSE)1. Journal Articles


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