Cited 13 time in webofscience Cited 13 time in scopus

Interplay between autophagy and programmed cell death in mammalian neural stem cells

Title
Interplay between autophagy and programmed cell death in mammalian neural stem cells
Authors
Chung, KM[Chung, Kyung Min]Yu, SW[Yu, Seong-Woon]
DGIST Authors
Chung, KM[Chung, Kyung Min]; Yu, SW[Yu, Seong-Woon]
Issue Date
2013-08-31
Citation
BMB Reports, 46(8), 383-390
Type
Article
Article Type
Review
Keywords
AgingAnimalAnimalsApoptosisAutophagic Cell DeathAutophagyCytologyDegenerative DiseaseHippocampusHumanHumansInsulinMetabolismNecrosisNervous System DevelopmentNeural Stem CellNeural Stem CellsNeurodegenerationNeurodegenerative DiseasesNeurogenesisPathologyProgrammed Cell Death
ISSN
1976-6696
Abstract
Mammalian neural stem cells (NSCs) are of particular interest because of their role in brain development and function. Recent findings suggest the intimate involvement of programmed cell death (PCD) in the turnover of NSCs. However, the underlying mechanisms of PCD are largely unknown. Although apoptosis is the best-defined form of PCD, accumulating evidence has revealed a wide spectrum of PCD encompassing apoptosis, autophagic cell death (ACD) and necrosis. This mini-review aims to illustrate a unique regulation of PCD in NSCs. The results of our recent studies on autophagic death of adult hippocampal neural stem (HCN) cells are also discussed. HCN cell death following insulin withdrawal clearly provides a reliable model that can be used to analyze the molecular mechanisms of ACD in the larger context of PCD. More research efforts are needed to increase our understanding of the molecular basis of NSC turnover under degenerating conditions, such as aging, stress and neurological diseases. Efforts aimed at protecting and harnessing endogenous NSCs will offer novel opportunities for the development of new therapeutic strategies for neuropathologies. [BMB Reports 2013; 46(8): 383-390]©2013 by the The Korean Society for Biochemistry and Molecular Biology.
URI
http://hdl.handle.net/20.500.11750/3213
DOI
10.5483/BMBRep.2013.46.8.164
Publisher
Korean Society for Biochemistry and Molecular Biology
Related Researcher
Files:
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Collection:
Brain and Cognitive SciencesETC1. Journal Articles
Brain and Cognitive SciencesLaboratory of Neuronal Cell Death1. Journal Articles


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