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Neuromodulatory State and Sex Specify Alternative Behaviors through Antagonistic Synaptic Pathways in C. elegans

Title
Neuromodulatory State and Sex Specify Alternative Behaviors through Antagonistic Synaptic Pathways in C. elegans
Authors
Jang, H[Jang, Heeun]Kim, K[Kim, Kyuhyung]Neal, SJ[Neal, Scott J.]Macosko, E[Macosko, Evan]Kim, D[Kim, Dongshin]Butcher, RA[Butcher, Rebecca A.]Zeiger, DM[Zeiger, Danna M.]Bargmann, CI[Bargmann, Cornelia I.]Sengupta, P[Sengupta, Piali]
DGIST Authors
Kim, K[Kim, Kyuhyung]
Issue Date
2012-08-23
Citation
Neuron, 75(4), 585-592
Type
Article
Article Type
Article
Keywords
Adaptive BehaviorAnalysis of VarianceAnimalsAnimals, Genetically ModifiedAscarosideCaenorhabditis ElegansCaenorhabditis Elegans ProteinsCalciumComplement C9Controlled StudyCrossover ProcedureDose-Response Relationship, DrugDrug InteractionsEscape ReactionFemaleGap JunctionGreen Fluorescent ProteinsImmunologic FactorsLuminescent ProteinsMaleMutationNerve Cell NetworkNerve NetNerve Tissue ProteinsNeural PathwaysNeuromodulationNeuronsNeurotransmitter AgentsNon-HumanPheromonePheromonesPriority JournalReaction TimeReceptors, Neuropeptide YReceptors, OdorantSensory Nerve CellSensory StimulationSex CharacteristicsSex DifferenceSignal TransductionSynapsesSynaptic TransmissionTransient Receptor Potential ChannelsUnclassified Drug
ISSN
0896-6273
Abstract
Pheromone responses are highly context dependent. For example, the C. elegans pheromone ascaroside C9 (ascr#3) is repulsive to wild-type hermaphrodites, attractive to wild-type males, and usually neutral to "social" hermaphrodites with reduced activity of the npr-1 neuropeptide receptor gene. We show here that these distinct behavioral responses arise from overlapping push-pull circuits driven by two classes of pheromone-sensing neurons. The ADL sensory neurons detect C9 and, in wild-type hermaphrodites, drive C9 repulsion through their chemical synapses. In npr-1 mutant hermaphrodites, C9 repulsion is reduced by the recruitment of a gap junction circuit that antagonizes ADL chemical synapses. In males, ADL sensory responses are diminished; in addition, a second pheromone-sensing neuron, ASK, antagonizes C9 repulsion. The additive effects of these antagonistic circuit elements generate attractive, repulsive, or neutral pheromone responses. Neuronal modulation by circuit state and sex, and flexibility in synaptic output pathways, may permit small circuits to maximize their adaptive behavioral outputs. © 2012 Elsevier Inc.
URI
http://hdl.handle.net/20.500.11750/3341
DOI
10.1016/j.neuron.2012.06.034
Publisher
Cell Press
Related Researcher
  • Author Kim, Kyu Hyung The K. Kim Lab of Neurobehavior and Neural Circuits
  • Research Interests
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesETC1. Journal Articles


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