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Activity of the mitochondrial calcium uniporter varies greatly between tissues

Title
Activity of the mitochondrial calcium uniporter varies greatly between tissues
Authors
Fieni, F.[Fieni, Francesca]Lee, S.B.[Lee, Sung Bae]Jan, Y.N.[Jan, Yuhnung]Kirichok, Y.[Kirichok, Yuriy V.]
DGIST Authors
Lee, S.B.[Lee, Sung Bae]
Issue Date
2012
Citation
Nature Communications, 3
Type
Article
Article Type
Article
Keywords
Animal ExperimentAnimal TissueApoptosisBrown Adipose TissueCalciumCalcium CurrentCalcium TransportCell VolumeComparative StudyFlight MuscleHeart MitochondrionKidneyLiverMembraneMetabolismMitochondrial DNAMitochondrial MembraneMouseNon-HumanRodentSkeletal Muscle
ISSN
2041-1723
Abstract
The mitochondrial calcium uniporter is a highly selective channel responsible for mitochondrial Ca 2+uptake. The mitochondrial calcium uniporter shapes cytosolic Ca 2+signals, controls mitochondrial ATP production, and is involved in cell death. Here using direct patch-clamp recording from the inner mitochondrial membrane, we compare mitochondrial calcium uniporter activity in mouse heart, skeletal muscle, liver, kidney and brown fat. Surprisingly, heart mitochondria show a dramatically lower mitochondrial calcium uniporter current density than the other tissues studied. Similarly, in Drosophila flight muscle, mitochondrial calcium uniporter activity is barely detectable compared with that in other fly tissues. As mitochondria occupy up to 40% of the cell volume in highly metabolically active heart and flight muscle, low mitochondrial calcium uniporter activity is likely essential to avoid cytosolic Ca 2+sink due to excessive mitochondrial Ca 2+uptake. Simultaneously, low mitochondrial calcium uniporter activity may also prevent mitochondrial Ca 2+overload in such active tissues exposed to frequent cytosolic Ca 2+activity. © 2012 Macmillan Publishers Limited. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/3402
DOI
10.1038/ncomms2325
Publisher
Nature Publishing Group
Files:
There are no files associated with this item.
Collection:
ETC1. Journal Articles


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