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dc.contributor.author Han, Sang Hee -
dc.contributor.author Kim, Sang Kyu -
dc.contributor.author Park, Kyoungsook -
dc.contributor.author Yi, So Yeon -
dc.contributor.author Park, Hye-Jung -
dc.contributor.author Lyu, Hong-Kun -
dc.contributor.author Kim, Moonil -
dc.contributor.author Chung, Bong Hyun -
dc.date.available 2017-07-11T07:12:23Z -
dc.date.created 2017-04-10 -
dc.date.issued 2010-04-14 -
dc.identifier.issn 0003-2670 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/3527 -
dc.description.abstract We assessed the abilities of wild p53 and mutant p53 proteins to interact with the consensus DNA-binding sequence using a MOSFET biosensor. This is the first report in which mutant p53 has been detected on the basis of DNA-protein interaction using a FET-type biosensor. In an effort to evaluate the performance of this protocol, we constructed the core domain of wild p53 and mutant p53 (R248W), which is DNA-binding-defective. After the immobilization of the cognate DNA to the sensing layer, wild p53 and mutant p53 were applied to the DNA-coated gate surface, and subsequently analyzed using a semiconductor analyzer. As a consequence, a significant up-shift in drain current was noted in response to wild p53, but not mutant p53, thereby indicating that sequence-specific DNA-protein interactions could be successfully monitored using a field-effect-based biosensor. These data also corresponded to the results obtained using surface plasmon resonance (SPR) measurements. Taken together, our results show that a FET-type biosensor might be promising for the monitoring of mutant p53 on the basis of its DNA-binding activity, providing us with very valuable insights into the monitoring for diseases, particularly those associated with DNA-protein binding events. © 2010 Elsevier B.V. -
dc.publisher Elsevier B.V. -
dc.title Detection of mutant p53 using field-effect transistor biosensor -
dc.type Article -
dc.identifier.doi 10.1016/j.aca.2010.03.006 -
dc.identifier.wosid 000277329300012 -
dc.identifier.scopusid 2-s2.0-77951209238 -
dc.identifier.bibliographicCitation Analytica Chimica Acta, v.665, no.1, pp.79 - 83 -
dc.subject.keywordAuthor Metal oxide semiconductor field-effect transistor -
dc.subject.keywordAuthor Biosensor -
dc.subject.keywordAuthor p53 -
dc.subject.keywordAuthor Mutant p53 -
dc.subject.keywordAuthor DNA-binding domain -
dc.subject.keywordPlus Article -
dc.subject.keywordPlus Binding -
dc.subject.keywordPlus Biochemistry -
dc.subject.keywordPlus Biosensing Techniques -
dc.subject.keywordPlus Biosensor -
dc.subject.keywordPlus BIOSENSORS -
dc.subject.keywordPlus CANCER -
dc.subject.keywordPlus CELL -
dc.subject.keywordPlus CHARGE -
dc.subject.keywordPlus Controlled Study -
dc.subject.keywordPlus DATABASE -
dc.subject.keywordPlus DNA -
dc.subject.keywordPlus DNA-Binding -
dc.subject.keywordPlus DNA-Binding Domain -
dc.subject.keywordPlus DNA-Protein Interaction -
dc.subject.keywordPlus DOMAIN -
dc.subject.keywordPlus Drain Current -
dc.subject.keywordPlus Fet-Type Biosensors -
dc.subject.keywordPlus Field-Effect -
dc.subject.keywordPlus Field Effect Transistor -
dc.subject.keywordPlus Field Effect Transistors -
dc.subject.keywordPlus Gene -
dc.subject.keywordPlus Gene Mutation -
dc.subject.keywordPlus Genes -
dc.subject.keywordPlus HUMAN TUMORS -
dc.subject.keywordPlus Mesfet Devices -
dc.subject.keywordPlus Metal Oxide Semiconductor Field-Effect Transistor -
dc.subject.keywordPlus Metal Oxide Semiconductor Field-Effect Transistors -
dc.subject.keywordPlus Metallic Compounds -
dc.subject.keywordPlus Monitoring -
dc.subject.keywordPlus MOS-FET -
dc.subject.keywordPlus Mos Devices -
dc.subject.keywordPlus Mutagenesis, Site-Directed -
dc.subject.keywordPlus Mutant P53 -
dc.subject.keywordPlus Mutant Protein -
dc.subject.keywordPlus Mutation -
dc.subject.keywordPlus P53 -
dc.subject.keywordPlus P53 Protein -
dc.subject.keywordPlus Priority Journal -
dc.subject.keywordPlus Protein Binding -
dc.subject.keywordPlus Protein DNA Interaction -
dc.subject.keywordPlus Protein Immobilization -
dc.subject.keywordPlus Protein P53 -
dc.subject.keywordPlus Protein Structure, Tertiary -
dc.subject.keywordPlus Proteins -
dc.subject.keywordPlus Recombinant Proteins -
dc.subject.keywordPlus Semiconductor Analyzer -
dc.subject.keywordPlus Sensing Layers -
dc.subject.keywordPlus Surface Plasmon Resonance -
dc.subject.keywordPlus Surface Property -
dc.subject.keywordPlus Transistors, Electronic -
dc.subject.keywordPlus Tumor Suppressor Protein P53 -
dc.citation.endPage 83 -
dc.citation.number 1 -
dc.citation.startPage 79 -
dc.citation.title Analytica Chimica Acta -
dc.citation.volume 665 -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Chemistry -
dc.relation.journalWebOfScienceCategory Chemistry, Analytical -
dc.type.docType Article -
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