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Magnetically Actuated Microscaffold Containing Mesenchymal Stem Cells for Articular Cartilage Repair
- Magnetically Actuated Microscaffold Containing Mesenchymal Stem Cells for Articular Cartilage Repair
- Go, Gwangjun; Han, Jiwon; Zhen, Jin; Zheng, Shaohui; Yoo, Ami; Jeon, Mi-Jeong; Park, Jong-Oh; Park, Sukho
- DGIST Authors
- Park, Sukho
- Issue Date
- Advanced Healthcare Materials, 6(13)
- Article Type
- Amine; Animal Cell; Articular Cartilage; Articular Cartilage Repair; Cell Adhesion; Cell Culture; Cell Differentiation; Cell Function; Cell Migration; Cell Proliferation; Cell Viability; Chemical Structure; Chondrocytes; Controlled Study; Iron; Locomotion; Magnetic Field; Magnetic Nano Particle; Material Coating; Mesenchymal Stem Cell; Mesenchymal Stem Cells; Micro Emulsion; Microspheres; Mouse; Nanoparticles; Non Human; Polyglactin; Porous Beads; Porous Scaffold Beads; Priority Journal; Regenerative Medicine; Scaffolds; System; Tissue Regeneration; Tissue Repair; Tissue Scaffold; Transforming Growth Factor Beta 1; Transplantation; Velocity
- This study proposes a magnetically actuated microscaffold with the capability of targeted mesenchymal stem cell (MSC) delivery for articular cartilage regeneration. The microscaffold, as a 3D porous microbead, is divided into body and surface portions according to its materials and fabrication methods. The microscaffold body, which consists of poly(lactic-co-glycolic acid) (PLGA), is formed through water-in-oil-in-water emulsion templating, and its surface is coated with amine functionalized magnetic nanoparticles (MNPs) via amino bond formation. The porous PLGA structure of the microscaffold can assist in cell adhesion and migration, and the MNPs on the microscaffold can make it possible to steer using an electromagnetic actuation system that provides external magnetic fields for the 3D locomotion of the microscaffold. As a fundamental test of the magnetic response of the microscaffold, it is characterized in terms of the magnetization curve, velocity, and 3D locomotion of a single microscaffold. In addition, its function with a cargo of MSCs for cartilage regeneration is demonstrated from the proliferation, viability, and chondrogenic differentiation of D1 mouse MSCs that are cultured on the microscaffold. For the feasibility tests for cartilage repair, 2D/3D targeting of multiple microscaffolds with the MSCs is performed to demonstrate targeted stem cell delivery using the microscaffolds and their swarm motion. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
- Wiley-VCH Verlag
- Related Researcher
Park, Suk Ho
Multiscale Biomedical Robotics Laboratory
Biomedical Micro/Nano Robotics; Biomedical Devices and Instruments
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