Cited 3 time in webofscience Cited 4 time in scopus

Nanohybrid magnetic liposome functionalized with hyaluronic acid for enhanced cellular uptake and near-infrared-triggered drug release

Title
Nanohybrid magnetic liposome functionalized with hyaluronic acid for enhanced cellular uptake and near-infrared-triggered drug release
Authors
Van Du NguyenZheng, ShaohuiHan, JiwonViet Ha LePark, Jong-OhPark, Sukho
DGIST Authors
Park, Sukho
Issue Date
2017-06-01
Citation
Colloids and Surfaces B-Biointerfaces, 154, 104-114
Type
Article
Article Type
Article
Keywords
Anti Cancer DrugsAntitumor ActivityBreast CancerCancer CellsCD44 ReceptorClinical ApplicationsCoated LiposomesHyaluronic AcidIn VitroNanohybrid LiposomePhotothermal TherapyPhotothermal TherapyPolymer Hybrid NanoparticlesSensitive LiposomesTargeted Co DeliveryTargeted Drug Delivery
ISSN
0927-7765
Abstract
The aim of this work is to prepare and evaluate a novel lipid-polymer hybrid liposomal nanoplatform (hyaluronic acid-magnetic nanoparticle-liposomes, HA-MNP-LPs) as a vehicle for targeted delivery and triggered release of an anticancer drug (docetaxel, DTX) in human breast cancer cells. We first synthesize an amphiphilic hyaluronic acid hexadecylamine polymer (HA-C-16) to enhance the targeting ability of the hybrid liposome. Next, HA-MNP-LPs are constructed to achieve an average size of 189.93 +/- 2.74 nm in diameter. In addition, citric acid-coated magnetic nanoparticles (MNPs) are prepared and embedded in the aqueous cores while DTX is encapsulated in the hydrophobic bilayers of the liposomes. Experiments with coumarin 6 loaded hybrid liposomes (C6/HA-MNP-LPs) show that the hybrid liposomes have superior cellular uptake in comparison with the conventional non-targeting liposomes (C6/MNP-LPs), and the result is further confirmed by Prussian blue staining. Under near-infrared laser irradiation (NIR, 808 nm), the HA-MNP-LPs aqueous solution can reach 46.7 degrees C in 10 min, and the hybrid liposomes released over 20% more drug than the non-irradiated liposomes. Using a combination of photothermal irradiation and chemotherapy, the DTX-loaded hybrid liposomes (DTX/HA-MNP-LPs) significantly enhance therapeutic efficacy, with the IC50 value of 0.69 +/- 0.10 mu g/mL, which is much lower than the values for DTX monotherapy. Consequently, the prepared hybrid nanoplatform may offer a promising drug delivery vehicle with selective targeting and enhanced drug release in treating CD44-overexpressing cancers. (C) 2017 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/4159
DOI
10.1016/j.colsurfb.2017.03.008
Publisher
ELSEVIER SCIENCE BV
Related Researcher
  • Author Park, Suk Ho Multiscale Biomedical Robotics Laboratory
  • Research Interests Biomedical Micro/Nano Robotics; Biomedical Devices and Instruments
Files:
There are no files associated with this item.
Collection:
Robotics EngineeringETC1. Journal Articles
ETC1. Journal Articles


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