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dc.contributor.author Van Du Nguyen -
dc.contributor.author Zheng, Shaohui -
dc.contributor.author Han, Jiwon -
dc.contributor.author Viet Ha Le -
dc.contributor.author Park, Jong-Oh -
dc.contributor.author Park, Sukho -
dc.date.available 2017-08-10T08:11:48Z -
dc.date.created 2017-08-09 -
dc.date.issued 2017-06 -
dc.identifier.citation Colloids and Surfaces B: Biointerfaces, v.154, pp.104 - 114 -
dc.identifier.issn 0927-7765 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/4159 -
dc.description.abstract The aim of this work is to prepare and evaluate a novel lipid-polymer hybrid liposomal nanoplatform (hyaluronic acid-magnetic nanoparticle-liposomes, HA-MNP-LPs) as a vehicle for targeted delivery and triggered release of an anticancer drug (docetaxel, DTX) in human breast cancer cells. We first synthesize an amphiphilic hyaluronic acid hexadecylamine polymer (HA-C-16) to enhance the targeting ability of the hybrid liposome. Next, HA-MNP-LPs are constructed to achieve an average size of 189.93 +/- 2.74 nm in diameter. In addition, citric acid-coated magnetic nanoparticles (MNPs) are prepared and embedded in the aqueous cores while DTX is encapsulated in the hydrophobic bilayers of the liposomes. Experiments with coumarin 6 loaded hybrid liposomes (C6/HA-MNP-LPs) show that the hybrid liposomes have superior cellular uptake in comparison with the conventional non-targeting liposomes (C6/MNP-LPs), and the result is further confirmed by Prussian blue staining. Under near-infrared laser irradiation (NIR, 808 nm), the HA-MNP-LPs aqueous solution can reach 46.7 degrees C in 10 min, and the hybrid liposomes released over 20% more drug than the non-irradiated liposomes. Using a combination of photothermal irradiation and chemotherapy, the DTX-loaded hybrid liposomes (DTX/HA-MNP-LPs) significantly enhance therapeutic efficacy, with the IC50 value of 0.69 +/- 0.10 mu g/mL, which is much lower than the values for DTX monotherapy. Consequently, the prepared hybrid nanoplatform may offer a promising drug delivery vehicle with selective targeting and enhanced drug release in treating CD44-overexpressing cancers. (C) 2017 Elsevier B.V. All rights reserved. -
dc.language English -
dc.publisher Elsevier BV -
dc.title Nanohybrid magnetic liposome functionalized with hyaluronic acid for enhanced cellular uptake and near-infrared-triggered drug release -
dc.type Article -
dc.identifier.doi 10.1016/j.colsurfb.2017.03.008 -
dc.identifier.wosid 000402348000014 -
dc.identifier.scopusid 2-s2.0-85015444020 -
dc.type.local Article(Overseas) -
dc.type.rims ART -
dc.description.journalClass 1 -
dc.citation.publicationname Colloids and Surfaces B: Biointerfaces -
dc.contributor.nonIdAuthor Van Du Nguyen -
dc.contributor.nonIdAuthor Zheng, Shaohui -
dc.contributor.nonIdAuthor Han, Jiwon -
dc.contributor.nonIdAuthor Viet Ha Le -
dc.contributor.nonIdAuthor Park, Jong-Oh -
dc.identifier.citationVolume 154 -
dc.identifier.citationStartPage 104 -
dc.identifier.citationEndPage 114 -
dc.identifier.citationTitle Colloids and Surfaces B: Biointerfaces -
dc.type.journalArticle Article -
dc.description.isOpenAccess N -
dc.subject.keywordAuthor Nanohybrid liposome -
dc.subject.keywordAuthor Photothermal therapy -
dc.subject.keywordAuthor Targeted drug delivery -
dc.subject.keywordAuthor Hyaluronic acid -
dc.subject.keywordAuthor CD44 receptor -
dc.subject.keywordAuthor Breast cancer -
dc.subject.keywordPlus POLYMER HYBRID NANOPARTICLES -
dc.subject.keywordPlus TARGETED CO-DELIVERY -
dc.subject.keywordPlus CANCER-CELLS -
dc.subject.keywordPlus CLINICAL-APPLICATIONS -
dc.subject.keywordPlus PHOTOTHERMAL THERAPY -
dc.subject.keywordPlus SENSITIVE LIPOSOMES -
dc.subject.keywordPlus ANTITUMOR-ACTIVITY -
dc.subject.keywordPlus ANTICANCER DRUGS -
dc.subject.keywordPlus COATED LIPOSOMES -
dc.subject.keywordPlus IN-VITRO -
dc.contributor.affiliatedAuthor Van Du Nguyen -
dc.contributor.affiliatedAuthor Zheng, Shaohui -
dc.contributor.affiliatedAuthor Han, Jiwon -
dc.contributor.affiliatedAuthor Viet Ha Le -
dc.contributor.affiliatedAuthor Park, Jong-Oh -
dc.contributor.affiliatedAuthor Park, Sukho -
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Department of Robotics and Mechatronics Engineering Multiscale Biomedical Robotics Laboratory 1. Journal Articles

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