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Concentric manipulation and monitoring of protein-loaded superparamagnetic cargo using magnetophoretic spider web
- Concentric manipulation and monitoring of protein-loaded superparamagnetic cargo using magnetophoretic spider web
- Lim, Byeonghwa; Torati, Sri Ramulu; Kim, Kun Woo; Hu, Xinghao; Reddy, Venu; Kim, CheolGi
- DGIST Authors
- Lim, Byeonghwa; Torati, Sri Ramulu; Kim, Kun Woo; Reddy, Venu; Kim, CheolGi
- Issue Date
- Npg Asia Materials, 9
- Article Type
- Biosensors; Domain Wall Conduits; Limits; Magnetic Particles; Medicine; Nanoparticles; On Chip Manipulation; Sensitivity; System
- A lab-on-a-chip (LOC) magnetophoretic system for the remotely controllable transport of magnetic particles actuated by thin permalloy magnetic tracks has been developed as a novel architecture composed of radii and spiral tracks resembling a spider web network, where the network tracks have the asymmetric and anisotropic magnetic properties for the directional transportation of particles (cargos). A planar Hall resistance (PHR) sensor is integrated with the web networks, and the manipulation and detection are achieved via superparamagnetic particles with dual functions as a biomolecule cargo for transportation and labels for monitoring. The streptavidin protein-coated magnetic particles are precisely manipulated toward the PHR sensor surface via the radii and spiral tracks by applying an external rotating magnetic field. The stray field was analyzed in terms of the particle coverage on the sensor surface, where the sensor signal linearly varies with the number of particles on the sensor surface. This allows the effective collection of low-density biomolecule carriers to one specific point and monitors the accumulated carriers. The developed novel technology could affect multiple fields, including bioassays, cell manipulation and separation and biomechanics.
- NATURE PUBLISHING GROUP
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- Emerging Materials ScienceLab for NanoBio-Materials & SpinTronics(nBEST)1. Journal Articles
Emerging Materials ScienceETC1. Journal Articles
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