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Concentric manipulation and monitoring of protein-loaded superparamagnetic cargo using magnetophoretic spider web

Title
Concentric manipulation and monitoring of protein-loaded superparamagnetic cargo using magnetophoretic spider web
Authors
Lim, ByeonghwaTorati, Sri RamuluKim, Kun WooHu, XinghaoReddy, VenuKim, CheolGi
DGIST Authors
Lim, Byeonghwa; Torati, Sri Ramulu; Kim, Kun Woo; Reddy, Venu; Kim, CheolGi
Issue Date
2017-03
Citation
Npg Asia Materials, 9
Type
Article
Article Type
Article
Keywords
BiosensorsDomain Wall ConduitsLimitsMagnetic ParticlesMedicineNanoparticlesOn Chip ManipulationSensitivitySystem
ISSN
1884-4049
Abstract
A lab-on-a-chip (LOC) magnetophoretic system for the remotely controllable transport of magnetic particles actuated by thin permalloy magnetic tracks has been developed as a novel architecture composed of radii and spiral tracks resembling a spider web network, where the network tracks have the asymmetric and anisotropic magnetic properties for the directional transportation of particles (cargos). A planar Hall resistance (PHR) sensor is integrated with the web networks, and the manipulation and detection are achieved via superparamagnetic particles with dual functions as a biomolecule cargo for transportation and labels for monitoring. The streptavidin protein-coated magnetic particles are precisely manipulated toward the PHR sensor surface via the radii and spiral tracks by applying an external rotating magnetic field. The stray field was analyzed in terms of the particle coverage on the sensor surface, where the sensor signal linearly varies with the number of particles on the sensor surface. This allows the effective collection of low-density biomolecule carriers to one specific point and monitors the accumulated carriers. The developed novel technology could affect multiple fields, including bioassays, cell manipulation and separation and biomechanics.
URI
http://hdl.handle.net/20.500.11750/4229
DOI
10.1038/am.2017.37
Publisher
NATURE PUBLISHING GROUP
Files:
There are no files associated with this item.
Collection:
Emerging Materials ScienceLab for NanoBio-Materials & SpinTronics(nBEST)1. Journal Articles
Emerging Materials ScienceETC1. Journal Articles


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