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Thermo-sensitive assembly of the biomaterial REP reduces hematoma volume following collagenase-induced intracerebral hemorrhage in rats

Title
Thermo-sensitive assembly of the biomaterial REP reduces hematoma volume following collagenase-induced intracerebral hemorrhage in rats
Authors
Park, JoohyunKim, Jong YoulChoi, Seong-KyoonKim, Jae YoungKim, Jae HwanJeon, Won BaeLee, Jong Eun
DGIST Authors
Jeon, Won Bae
Issue Date
2017
Citation
Nanomedicine: Nanotechnology, Biology, and Medicine, 13(6), 1853-1862
Type
Article
Article Type
Article
Keywords
ElastinElastin Like PolypeptideElastin Like PolypeptidesGlycoproteinsInflammatory ResponseIntracerebral Hemorrhage (ICH)Intracerebral Hemorrhage (ICH)Intracerebral Hemorrhages (ICH)NanomaterialNano Structured MaterialsPolypeptidesRgd Containing Elastin Like PolypeptideSevere DisabilitiesTherapeutic StrategyThermally ResponsiveTumorsVon Willebrand Factor
ISSN
1549-9634
Abstract
Intracerebral hemorrhage (ICH) frequently results in severe disabilities and high mortality. RGD-containing elastin-like polypeptide (REP), a modified elastin-like polypeptide (ELP), is a thermally responsive biopolymer. REP has high affinity for cells and is known to show non-immunotoxicity, -cytotoxicity, and -inflammatory responses. Here we found that administration of REP in the acute phase of the ICH rat model reduced the hematoma volume, decreased the number of activated microglia, attenuated the expression of von Willebrand Factor (vWF), and prevented the leakage of immunoglobulin G (IgG) into the cerebral parenchyma without any occlusion of intact microvessels. Therefore, the present data suggest that REP treatment could be a novel therapeutic strategy for attenuating the acute phase of ICH. © 2017 The Author(s)
URI
http://hdl.handle.net/20.500.11750/4263
DOI
10.1016/j.nano.2017.04.001
Publisher
Elsevier Inc.
Related Researcher
Files:
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Collection:
Companion Diagnostics and Medical Technology Research Group1. Journal Articles


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