Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박천규 | - |
dc.contributor.author | 서병창 | - |
dc.date.available | 2017-08-10T08:19:08Z | - |
dc.date.created | 2017-08-09 | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 1933-6950 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/4266 | - |
dc.description.abstract | Recently, we showed that the HOOK region of the β2 subunit electrostatically interacts with the plasma membrane and regulates the current inactivation and phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of voltage-gated Ca2+ (CaV) 2.2 channels. Here, we report that voltage-dependent gating and current density of the CaV2.2 channels are also regulated by the HOOK region of the β2 subunit. The HOOK region can be divided into 3 domains: S (polyserine), A (polyacidic), and B (polybasic). We found that the A domain shifted the voltage-dependent inactivation and activation of CaV2.2 channels to more hyperpolarized and depolarized voltages, respectively, whereas the B domain evoked these responses in the opposite directions. In addition, the A domain decreased the current density of the CaV2.2 channels, while the B domain increased it. Together, our data demonstrate that the flexible HOOK region of the β2 subunit plays an important role in determining the overall CaV channel gating properties. © 2017 Taylor & Francis | - |
dc.publisher | Taylor and Francis Inc. | - |
dc.title | The HOOK region of subunits controls gating of voltage-gated Ca2+ channels by electrostatically interacting with plasma membrane | - |
dc.type | Article | - |
dc.identifier.doi | 10.1080/19336950.2017.1335841 | - |
dc.identifier.scopusid | 2-s2.0-85021216967 | - |
dc.identifier.bibliographicCitation | Channels, v.11, no.5, pp.467 - 475 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordAuthor | 2c subunit | - |
dc.subject.keywordAuthor | current density | - |
dc.subject.keywordAuthor | electrostatic interaction | - |
dc.subject.keywordAuthor | HOOK region | - |
dc.subject.keywordAuthor | plasma membrane | - |
dc.subject.keywordAuthor | voltage-dependent gating | - |
dc.subject.keywordAuthor | Voltage-gated Ca2+ (Ca-V) channel | - |
dc.subject.keywordPlus | BETA-SUBUNIT | - |
dc.subject.keywordPlus | FUNCTIONAL-PROPERTIES | - |
dc.subject.keywordPlus | TRAFFICKING | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.citation.endPage | 475 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 467 | - |
dc.citation.title | Channels | - |
dc.citation.volume | 11 | - |