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Systematic Analysis of Translocator Protein 18 kDa (TSPO) Ligands on Toll-like Receptors-mediated Pro-inflammatory Responses in Microglia and Astrocytes

Title
Systematic Analysis of Translocator Protein 18 kDa (TSPO) Ligands on Toll-like Receptors-mediated Pro-inflammatory Responses in Microglia and Astrocytes
Authors
Lee, Ji-WonNam, HyeriYu, Seong-Woon
DGIST Authors
Lee, Ji-Won; Nam, Hyeri; Yu, Seong-Woon
Issue Date
2016-10
Citation
Experimental Neurobiology, 25(5), 262-268
Type
Article
Article Type
Article
Keywords
AstrocyteMicrogliaPsychiatric DisordersToll Like ReceptorsTSPOTSPO Ligands
ISSN
1226-2560
Abstract
Translocator protein 18 kDa (TSPO) is a mitochondrial protein highly expressed on reactive microglia and astrocytes, and is considered as a biomarker for neurodegeneration and brain damage, especially neuroinflammation. Toll-like receptors (TLRs) are closely related with inflammatory responses of microglia and astrocytes and these signaling pathways regulate neuroinflammation. Previous reports have identified the anti-inflammatory effects of TSPO ligands, however study of their effects in relation to the TLR signaling was limited. Here, we investigated the effects of five representative TSPO ligands on microglia and astrocytes following activation by various TLR ligands. Our results show that TSPO ligands reduce the pro-inflammatory response elicited by the TLR ligands with more profound effects on microglia than astrocytes. © Experimental Neurobiology 2016.
URI
http://hdl.handle.net/20.500.11750/4424
DOI
10.5607/en.2016.25.5.262
Publisher
KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesLaboratory of Neuronal Cell Death1. Journal Articles


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