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Continuous topical drug delivery using osmotic pump in animal cochlear implant model: Continuous steroid delivery is effective for hearing preservation

Title
Continuous topical drug delivery using osmotic pump in animal cochlear implant model: Continuous steroid delivery is effective for hearing preservation
Authors
Lee, Min YoungLee, Jun HoLee, Ho SunChoi, Jun-JaeJang, JongmoonChoi, HongsooOh, Seung-HaJang, Jeong Hun
DGIST Authors
Jang, Jongmoon; Choi, Hongsoo
Issue Date
2015-08
Citation
Acta Oto-Laryngologica, 135(8), 791-798
Type
Article
Article Type
Article
Keywords
Albino Guinea PigAnimalAnimal ExperimentAnimal TissueAnimalsAudiometry, Pure ToneAuditory ThresholdAuditory ThresholdCochlea ProsthesisCochlear ImplantationCochlear ImplantsControlled StudyDexamethasoneDexamethasoneDisease ModelDisease Models, AnimalDrug Delivery SystemDrug Delivery SystemsDrug EffectsDrug EfficacyEvoked Brain Stem Auditory ResponseEvoked Potentials, Auditory, Brain StemFemaleFemaleGiant CellGuinea PigGuinea Pig ModelGuinea PigsHearingHearingHearing LossHearing ProtectionHistiocyteHistologyInnerEar FunctionInsertionNon HumanOsmotic PumpOtorhinolaryngology Drug Delivery DevicePathophysiologyPhysiologyPriority JournalProtectionPure Tone AudiometryResidual HearingRound Window DexamethasoneStimulationSurgeryTherapyTopical Drug AdministrationTrauma
ISSN
0001-6489
Abstract
Conclusions: Continuous topical drug delivery using an osmotic pump is an effective supplementary technique for hearing preservation after cochlear implantation, as demonstrated in a guinea pig model. Objective: To evaluate the effect of continuous topical steroid delivery via an osmotic pump in an animal cochlear implant model. Methods: Twenty-three guinea pigs were used for the study. The animals were divided into three groups: control group (n = 8), simple topical dexamethasone delivery group (sDEXA group, n = 7) and continuous topical dexamethasone delivery group (cDEXA, n = 8). The hearing thresholds of all animals were measured by pre-operative auditory brain stem responses (ABRs) at 2, 8, 16, 24, and 32 kHz. ABRs were re-evaluated after cochlear implantation, and the animals were sacrificed for hematoxylin and eosin staining. Results: The ABR threshold at 1 week post-operatively was significantly lower in the cDEXA group than in the control and sDEXA groups at most frequencies. Threshold shifts from baseline were statistically smaller in the cDEXA group than in the control and sDEXA groups at all frequencies. Histological analysis revealed decreased numbers of multi-nucleated giant cells and thinner histiocyte layers. © 2015 Informa Healthcare.
URI
http://hdl.handle.net/20.500.11750/4425
DOI
10.3109/00016489.2015.1030771
Publisher
Informa Healthcare
Files:
There are no files associated with this item.
Collection:
Robotics EngineeringBio-Micro Robotics Lab1. Journal Articles


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