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Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress

Title
Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress
Authors
Lee, Hwa-YoungKim, Seung-WookLee, Geum-HwaChoi, Min-KyungChung, Han-WoolLee, Yong-ChulKim, Hyung-RyongKwon, Ho JeongChae, Han-Jung
DGIST Authors
Kim, Hyung-Ryong
Issue Date
2017-07
Citation
Scientific Reports, 7
Type
Article
Article Type
Article
Keywords
Carbon TetrachlorideDysfunctionGlutathioneHepatotoxicityHuman DiseaseInflammationLiverMiceOxidative StressProtein Disulfide Isomerase
ISSN
2045-2322
Abstract
For this study, we examined the effects of curcumin against acute and chronic stress, paying specific attention to ROS. We also aimed to clarify the differences between acute and chronic stress conditions. We investigated the effects of curcumin against acute stress (once/1 day CCl4 treatment) and chronic-stress (every other day/4week CCl4 treatment). Compared with acute stress, in which the antioxidant system functioned properly and aspartate transaminase (AST) and ROS production increased, chronic stress increased AST, alanine aminotransferase (ALT), hepatic enzymes, and ROS more significantly, and the antioxidant system became impaired. We also found that ER-originated ROS accumulated in the chronic model, another difference between the two conditions. ER stress was induced consistently, and oxidative intra-ER protein folding status, representatively PDI, was impaired, especially in chronic stress. The PDI-associated client protein hepatic apoB accumulated with the PDI-binding status in chronic stress, and curcumin recovered the altered ER folding status, regulating ER stress and the resultant hepatic dyslipidemia. Throughout this study, curcumin and curcumin-rich Curcuma longa L. extract promoted recovery from CCl4-induced hepatic toxicity in both stress conditions. For both stress-associated hepatic dyslipidemia, curcumin and Curcuma longa L. extract might be recommendable to recover liver activity. © 2017 The Author(s).
URI
http://hdl.handle.net/20.500.11750/4446
DOI
10.1038/s41598-017-06872-y
Publisher
Nature Publishing Group
Files:
There are no files associated with this item.
Collection:
ETC1. Journal Articles


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