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Early Pheromone Experience Modifies a Synaptic Activity to Influence Adult Pheromone Responses of C. elegans

Title
Early Pheromone Experience Modifies a Synaptic Activity to Influence Adult Pheromone Responses of C. elegans
Authors
Hong, Myeong-JinRyu, Lee-SunOw, Maria C.Kim, JinmahnJe, A ReumChinta, SatyaHuh, Yang HoonLee, Kea JooButcher, Rebecca A.Choi, Hong-SooSengupta, PialiHall, Sarah E.Kim, Kyu-Hyung
DGIST Authors
Hong, Myeong-Jin; Ryu, Lee-Sun; Choi, Hong-SooKim, Kyu-Hyung
Issue Date
2017
Citation
Current Biology, 27(20), 3168-3177.e3
Type
Article
Article Type
Article
ISSN
0960-9822
Abstract
Experiences during early development can influence neuronal functions and modulate adult behaviors [1, 2]. However, the molecular mechanisms underlying the long-term behavioral effects of these early experiences are not fully understood. The C. elegans ascr#3 (asc-ΔC9; C9) pheromone triggers avoidance behavior in adult hermaphrodites [3–7]. Here, we show that hermaphrodites that are briefly exposed to ascr#3 immediately after birth exhibit increased ascr#3-specific avoidance as adults, indicating that ascr#3-experienced animals form a long-lasting memory or imprint of this early ascr#3 exposure [8]. ascr#3 imprinting is mediated by increased synaptic activity between the ascr#3-sensing ADL neurons and their post-synaptic SMB motor neuron partners via increased expression of the odr-2 glycosylated phosphatidylinositol (GPI)-linked signaling gene in the SMB neurons. Our study suggests that the memory for early ascr#3 experience is imprinted via alteration of activity of a single synaptic connection, which in turn shapes experience-dependent plasticity in adult ascr#3 responses. Hong et al. show that early pheromone experience in C. elegans hermaphrodites is imprinted via alteration of activity of a single synaptic connection and, in turn, modulates behavioral responses to the pheromone as adults. © 2017 Elsevier Ltd
URI
http://hdl.handle.net/20.500.11750/4631
DOI
10.1016/j.cub.2017.08.068
Publisher
Cell Press
Related Researcher
  • Author Choi, Hong Soo Bio-Micro Robotics Lab
  • Research Interests Micro/Nano robot; Neural prostheses; MEMS; BMI; MEMS/NEMS; BioMEMS; MEMS 초음파 트랜스듀스; 인공와우
Files:
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Collection:
Brain and Cognitive SciencesETC1. Journal Articles
Robotics EngineeringBio-Micro Robotics Lab1. Journal Articles


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