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Enhanced Therapeutic Treatment of Colorectal Cancer Using Surface-Modified Nanoporous Acupuncture Needles

Title
Enhanced Therapeutic Treatment of Colorectal Cancer Using Surface-Modified Nanoporous Acupuncture Needles
Authors
Lee, Bo RamKim, Hye RimChoi, Eun SookCho, Jung-HoonKim, Nam-JunKim, Jung HeeLee, Kyeong MinRazzaq, AbdulChoi, Han SaemHwang, Yun JuGrimes, Craig A.Lee, Bong-HyoKim, Eun JooIn, Su-Il
DGIST Authors
Lee, Bo Ram; Kim, Hye Rim; Choi, Eun Sook; Kim, Jung Hee; Lee, Kyeong Min; Razzaq, Abdul; Choi, Han Saem; Hwang, Yun Ju; Kim, Eun JooIn, Su-Il
Issue Date
2017-10
Citation
Scientific Reports, 7(1)
Type
Article
Article Type
Article
Keywords
Beta-CateninExpressionMouseColonPainRatPCR
ISSN
2045-2322
Abstract
Acupuncture originated within the auspices of Oriental medicine, and today is used as an alternative method for treating various diseases and symptoms. The physiological mechanisms of acupuncture appear to involve the release of endogenous opiates and neurotransmitters, with the signals mediating through electrical stimulation of the central nervous system (CNS). Earlier we reported a nanoporous stainless steel acupuncture needle with enhanced therapeutic properties, evaluated by electrophysiological and behavioral responses in Sprague-Dawley (SD) rats. Herein, we investigate molecular changes in colorectal cancer (CRC) rats by acupuncture treatment using the nanoporous needles. Treatment at acupoint HT7 is found most effective at reducing average tumor size, β-catenin expression levels, and the number of aberrant crypt foci in the colon endothelium. Surface modification of acupuncture needles further enhances the therapeutic effects of acupuncture treatment in CRC rats. © 2017 The Author(s).
URI
http://hdl.handle.net/20.500.11750/4703
DOI
10.1038/s41598-017-11213-0
Publisher
Nature Publishing Group
Related Researcher
Files:
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Collection:
Energy Science and EngineeringGreen and Renewable Energy for Endless Nature(GREEN) Lab1. Journal Articles
Companion Diagnostics and Medical Technology Research Group1. Journal Articles


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