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Impact of the localization of dendritic calcium persistent inward current on the input-output properties of spinal motoneuron pool: a computational study
- Impact of the localization of dendritic calcium persistent inward current on the input-output properties of spinal motoneuron pool: a computational study
- Kim, Ho Jeong
- DGIST Authors
- Kim, Ho Jeong
- Issue Date
- Journal of Applied Physiology, 123(5), 1166-1187
- Article Type
- IN-VIVO; MOTOR-UNIT; PLATEAU POTENTIALS; SYSTEMATIC VARIATIONS; ELECTRICAL-PROPERTIES; HINDLIMB MOTONEURONS; INTRINSIC-PROPERTIES; LUMBAR MOTONEURONS; ALPHA-MOTONEURONS; DECEREBRATE CATS
- The goal of this study is to investigate how the dendritic Ca-PIC location influences nonlinear input-output properties and depends on the type of motoneurons across the motoneuron pool. A model motoneuron pool consisting of 10 motoneurons was constructed using a recently developed two-compartment modeling approach that reflected key cell type-associated properties experimentally identified. The dendritic excitability and firing output depended systematically on both the PIC location and the motoneuron type. The PIC onset and offset in the current-voltage (I-V) relationship tended to occur at more hyperpolarized voltages as the path length to the PIC channels from the soma increased and as the cell type shifted from high- to lowthreshold motoneurons. At the same time, the firing acceleration and frequency hysteresis in the frequency-current (F-I) relationship became faster and larger, respectively. However, the PIC onset-offset hysteresis increased as the path length and the recruitment threshold increased. Furthermore, the gain of frequency-current function before full PIC activation was larger for PIC channels located over distal dendritic regions in low- compared with high-threshold motoneurons. When compared with previously published experimental observations, the modeling concurred when Ca-PIC channels were placed closer to the soma in high- than low-threshold motoneurons in the model motoneuron pool. All of these results suggest that the negative relationship of Ca-PIC location and cell recruitment threshold may underlie the systematic variation in I-V and F-I transformation across the motoneuron pool. NEW & NOTEWORTHY How does the dendritic location of calcium persistent inward current (Ca-PIC) influence dendritic excitability and firing behavior across the spinal motoneuron pool? This issue was investigated developing a model motoneuron pool that reflected key motoneuron type-specific properties experimentally identified. The simulation results point out the negative relationship between the distance of Ca-PIC source from the soma and cell recruitment threshold as a basis underlying the systematic variation in input-output properties of motoneurons over the motoneuron pool. © Copyright 2017 the American Physiological Society.
- American Physiological Society
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- Companion Diagnostics and Medical Technology Research Group1. Journal Articles
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